PMID: 9181384May 1, 1997Paper

Efficacy of twice-daily dosing of amoxycillin/clavulanate in acute otitis media in children

Infection
U BehreH E Harrison

Abstract

Children with acute otitis media (AOM), aged 2-12 years, were randomised to 10 days treatment with amoxycillin/clavulanate (A/C) 70/10 mg/kg/day given b.i.d. (231 patients) or to A/C 60/15 mg/kg/day given t.i.d. (232 patients). Clinical success rates at end of therapy (10-17 days) were 91.8% for the b.i.d. group and 90.5% for the t.i.d. group and at follow-up (28-42 days) were 80.1% for the b.i.d. group and 77.6% for the t.i.d. group, indicating that the b.i.d. regimen was as effective as the t.i.d. regimen. There was no statistically significant difference in incidence of adverse experiences between the two groups. The overall incidence of protocol defined diarrhoea assessed from diary booklets was low, with a lower incidence in the b.i.d. group (6.7%) than in the t.i.d. group (10.3%). Significantly more patients in the b.i.d. group (83.1%) than in the t.i.d. group (72.8%) had at least 80% compliance over a 7-10 day treatment period. A/C given twice or three-times daily was highly effective in the treatment of AOM in children. The two regimens showed equivalent clinical efficacy, both were well tolerated, and there was evidence of improved compliance with the b.i.d. regimen.

References

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Citations

Jun 16, 2005·International Journal of Pediatric Otorhinolaryngology·Nili SegalAlberto Leiberman
Aug 5, 2000·International Journal of Antimicrobial Agents·E Leibovitz, R Dagan
Feb 29, 2000·The Pediatric Infectious Disease Journal·R DaganM R Jacobs
Aug 2, 2002·Expert Opinion on Pharmacotherapy·Michael E Pichichero, Janet R Casey
Nov 7, 2007·International Journal of Antimicrobial Agents·Richard Bax
Jun 1, 1997·Journal of Chemotherapy·P BallG Rolinson
Feb 15, 2002·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·V MurbachF Jehl
Jul 3, 2016·Archives of Virology·Konstantinos Z VardakasMatthew E Falagas
Feb 28, 2007·Clinical Pediatrics·Stephanie M ChandlerDavid P McCormick
Mar 17, 2004·Clinical Pediatrics·Richard Linsk, James Cooke
Sep 1, 2004·American Journal of Veterinary Research·Sonja FranzWalter Baumgartner
Dec 18, 2013·The Cochrane Database of Systematic Reviews·Sanguansak ThanaviratananichPatravoot Vatanasapt
May 13, 2015·The Journal of Pediatric Pharmacology and Therapeutics : JPPT : the Official Journal of PPAG·Jemima KuehnMike Sharland
Jul 11, 2021·The Spine Journal : Official Journal of the North American Spine Society·Lars Christian Haugli BråtenUNKNOWN AIM study group

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