Efficacy of two alcohol-free cetylpyridinium chloride mouthwashes - a randomized double-blind crossover study

Journal of Clinical Periodontology
Andrew RawlinsonPhilip Wright

Abstract

(1) To determine the plaque inhibition properties of two formulations of alcohol-free mouthwash [0.1% w/w cetylpyridinium chloride (CPC) (B) and 0.05% w/w CPC (A)] versus a placebo mouthwash (C). (2) To compare the plaque-inhibiting activity between these two new CPC mouthwashes. A double-blind, crossover study with three 1-week periods was used. Subjects were randomly assigned to one of the following groups. Group 1 (n=10) received the mouthwashes A, C and B in the periods 1, 2 and 3, respectively, group 2 (n=11) received the mouthwashes in the order B, A, C, while group 3 (n=11) received the mouthwashes in the order C, B, A. Mean plaque areas and Quigley & Hein plaque index scores were analysed using anova (analysis of variance). Measurements were made at the start of each period (baseline) and at 16, 24 and 40 h. Mean plaque scores were similar across the groups at baseline. At all time points thereafter, volunteers using mouthwash A or B had significantly lower plaque areas and plaque index scores than those using mouthwash C (p<0.05), but there were no significant differences between the test formulations. At 16 h, the reduction in plaque area relative to mouthwash C was 22% for mouthwash A and 18% for mouthwash B; at 24 h...Continue Reading

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Citations

Apr 8, 2010·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·Kristin HegstadSiamak P Yazdankhah
May 4, 2011·Antimicrobial Agents and Chemotherapy·Audrey CorbinPhilip S Stewart
Mar 5, 2016·Journal of Oral Biology and Craniofacial Research·Sravan Kumar YeturuKalyana Chakravarthy Pentapati
Jan 15, 2017·Journal of Dentistry·Jinkyung KimSu-Hyung Hong
Dec 21, 2019·Journal of the Science of Food and Agriculture·Heon-Jin LeeSu-Hyung Hong
Aug 27, 2019·Journal of Esthetic and Restorative Dentistry : Official Publication of the American Academy of Esthetic Dentistry ... [et Al.]·Jorge Rodríguez-MartínezMaría-Jesús Sánchez-Martín

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