PMID: 6987185Jan 1, 1980Paper

Efficacy of undecylenic acid-zinc undecylenate powder in culture positive tinea pedis

International Journal of Dermatology
J H ChretienF E Lyddon

Abstract

One hundred fifty-one patients with tinea pedis participated in a double-blind study to assess the efficacy and safety of a powder containing undecylenic acid 2% and zinc undecylenate 20% versus a placebo powder. Patients were assigned to apply twice-daily applications of either active powder or placebo for a period of 4 weeks. Trichophyton rubrum or Trichophyton mentagrophytes were isolated from pretreatment cultures of 85 patients. Of these, 88% treated with active powder had negative cultures after 4 weeks compared with 17% of those treated with placebo powder (p less than 0.001). Fungus was identified in potassium hydroxide (KOH) treated skin scrapings of all 151 patients before treatment. Of those treated with active powder, 80% were KOH negative after 4 weeks compared with 49% of those treated with placebow powder (p = 0.001). Erythema and scaling were significantly improved by therapy with active powder, as were subjective evaluations of itching and burning. There were no side-effects or adverse reactions to undecylenic acid and its zinc salt.

References

Jan 1, 1977·International Journal of Dermatology·E B SmithJ A Ulrich
Jun 1, 1977·Postgraduate Medicine·J J Leyden, A M Kligman
Oct 1, 1946·The Journal of Investigative Dermatology·J G HOPKINS, J K FISHER
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Citations

Jan 8, 2014·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Zoe D Draelos
May 3, 2005·The Journal of General and Applied Microbiology·Ana Graci Brito-MadurroAntonio Rossi
Jul 21, 2005·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·James R SchwartzZoe Diana Draelos
Aug 15, 2014·Dermatology Research and Practice·Mrinal GuptaPushpinder S Chauhan
Sep 1, 1981·Journal of the American Academy of Dermatology·R L Dobson, P F Nelson
Oct 7, 2008·The British Journal of Dermatology·F CrawfordH C Williams
Sep 6, 2003·Dermatologic Clinics·Aditya K GuptaRaza Aly
Mar 1, 1983·The Physician and Sportsmedicine·L W Stauffer
Dec 1, 1984·International Journal of Dermatology·D E Vander Ploeg, R L De Villez
Jul 20, 2007·The Cochrane Database of Systematic Reviews·F Crawford, S Hollis
Dec 8, 2020·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Ab Latif WaniMohammad Afzal

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