Efficacy of vasopressin/terlipressin and somatostatin/octreotide for the prevention of early variceal rebleeding after the initial control of bleeding: a systematic review and meta-analysis

Hepatology International
Chao WangZhen Yang

Abstract

Our purpose was to conduct a meta-analysis to compare the effectiveness of vasopressin/terlipressin and somatostatin/octreotide on variceal re-bleeding within and after 5 days of initial control bleeding. A search was conducted of PubMed, the Cochrane database, and Google Scholar until June 31, 2014 using combinations of the search terms: esophageal varices, variceal re-bleeding, recurrent variceal hemorrhage, early re-bleeding, vasopressin, somatostatin, terlipressin, octreotide. Inclusion criteria were: (1) randomized controlled trials, (2) patients with esophageal or esophageal and gastric varices confirmed by endoscopy, (3) re-bleeding control was evaluated, (4) treatment with somatostatin/vasopressin. Outcome measures were the re-bleeding rates within 5 days (≤ 5 days) or after 5 days (>5 days) after initial treatment. Six studies were included in the analysis. Five studies had complete data of re-bleeding rate within 5 days after initial treatment, and the combined odds ratio (OR) of 0.87 [95% confidence interval (CI) 0.51, 1.50] indicated that there was no difference in the re-bleeding rate between patients treated with vasopressin/terlipressin or somatostatin/octreotide. Two studies had complete data of the re-bleeding ...Continue Reading

References

Jun 1, 1992·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·S WalkerJ C Bode
Sep 1, 1990·Journal of Gastroenterology and Hepatology·K W ChiuY F Liaw
Feb 1, 1989·Journal of Clinical Gastroenterology·J G FreemanC O Record
May 1, 1982·Annals of Internal Medicine·M R FogelP B Gregory
Jul 1, 1993·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·C SilvainM Doffël
Mar 1, 1997·Journal of Hepatology·A EscorsellJ Rodés
Jun 1, 1997·Baillière's Clinical Gastroenterology·G D'Amico, A Luca
Jun 14, 2000·BMJ : British Medical Journal·A J SuttonD R Jones
Aug 29, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A EscorsellJ Bosch
Mar 7, 2001·Gastroenterology·D A CorleyK Kerlikowske
May 2, 2001·The Cochrane Database of Systematic Reviews·G IoannouD C Rockey
May 25, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Juan G Abraldes, Jaime Bosch
Dec 21, 2002·Alimentary Pharmacology & Therapeutics·G N IoannouD C Rockey
Jan 22, 2003·The Cochrane Database of Systematic Reviews·G IoannouD C Rockey
Jul 10, 2003·Gastroenterology·Michael A Heneghan, Don C Rockey
Apr 14, 2004·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·R de Franchis
Dec 13, 2007·Journal of Clinical Gastroenterology·Juan G Abraldes, Jaime Bosch
Dec 21, 2007·Journal of Hepatology·Juan G AbraldesUNKNOWN Spanish Cooperative Group for Portal Hypertension and Variceal Bleeding
Aug 5, 2008·The Cochrane Database of Systematic Reviews·Peter C Gøtzsche, Asbjørn Hróbjartsson
Mar 5, 2010·The New England Journal of Medicine·Guadalupe Garcia-Tsao, Jaime Bosch
Jun 1, 2011·The American Journal of Gastroenterology·Salvador AugustinJoan Genescà
Mar 27, 2012·Seminars in Respiratory and Critical Care Medicine·Juan Carlos García-PagánJaime Bosch
Apr 11, 2012·Alimentary Pharmacology & Therapeutics·M WellsM Mrkobrada
Jan 15, 2014·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Yeon Seok SeoSoon Ho Um

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Citations

Nov 20, 2015·Expert Review of Gastroenterology & Hepatology·Michael J Williams, Peter Hayes
Mar 17, 2016·Expert Review of Gastroenterology & Hepatology·N KimerF Bendtsen
Feb 7, 2018·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Tara L MolinaSara Varnado
Mar 4, 2020·International Journal of Molecular Sciences·Mariana Gomes-PorrasCristina Álvarez-Escolá
Jan 31, 2019·World Journal of Gastrointestinal Pharmacology and Therapeutics·Umesha BoregowdaShreyas Saligram
Nov 1, 2020·BMC Gastroenterology·Cyriac Abby PhilipsPhilip Augustine
Nov 13, 2020·World Journal of Gastroenterology : WJG·Lakmie S GunarathneChandana B Herath
May 8, 2021·Journal of the American College of Radiology : JACR·UNKNOWN Expert Panels on Interventional Radiology and Vascular ImagingEric J Hohenwalter

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