Efficacy of voriconazole in a murine model of invasive paecilomycosis

International Journal of Antimicrobial Agents
M Mar RodríguezJosep Guarro

Abstract

We studied the efficacy of voriconazole (VRC) and amphotericin B (AMB) in an immunosuppressed murine model of disseminated infection by two strains of Paecilomyces lilacinus. Mice were treated with VRC 60 mg/kg/day orally or AMB 3mg/kg/day intraperitoneally, beginning 1 day after infection and continuing for 9 days. To avoid rapid clearance of VRC, animals receiving VRC and the control group were given grapefruit juice instead of water. VRC significantly prolonged survival with respect to the group treated with AMB and the control group for both strains (P=0.005 and P<0.0001, respectively, for strain FMR 5522; and P=0.0002 and P<0.0001, respectively, for strain FMR 8252). VRC reduced the fungal load in the spleen, kidneys and liver of infected mice for both strains tested. Survival of mice challenged with strain FMR 8252 treated with AMB did not differ from that of the control group (P=0.223), being worse than that of the mice treated with VRC (P=0.0002). AMB was not able to reduce the tissue burden in any organ with respect to the control group for both strains studied.

References

Jan 1, 1992·Eye·L W HirstK Stallard
Sep 1, 1991·Ophthalmology·G D'MellowK Stallard
Jan 1, 1990·Journal of Medical and Veterinary Mycology : Bi-monthly Publication of the International Society for Human and Animal Mycology·L G CastroM N Sotto
Oct 1, 1986·Archives of Dermatology·K B JadeJ W Gnann
Aug 1, 1997·Journal of the American Academy of Dermatology·M S HeckerR G Phelps
Aug 19, 1999·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·N M Clark
Dec 10, 1999·The Journal of Antimicrobial Chemotherapy·J GuarroI Pujol
Dec 30, 1999·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·F Gutiérrez-RoderoC Martín
Feb 13, 2001·Antimicrobial Agents and Chemotherapy·A M Sugar, X P Liu
Sep 14, 2002·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Craig A MartinRichard N Greenberg
Oct 11, 2002·Scandinavian Journal of Infectious Diseases·Jorge GarbinoEdoardo Baligvo
May 15, 2003·The Journal of Antimicrobial Chemotherapy·John R GraybillRosie Bocanegra
Oct 2, 2003·Emerging Infectious Diseases·Jeanne CareyMichael G Rinaldi
Sep 11, 2004·International Journal of Dermatology·Virginia C HallJohn S Walsh
Sep 12, 2006·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·F J Pastor, J Guarro
Jul 4, 2007·Transplant Infectious Disease : an Official Journal of the Transplantation Society·T Van SchooneveldP C Iwen
Dec 5, 2008·The Journal of Antimicrobial Chemotherapy·M Mar RodríguezJosep Guarro
Feb 7, 2009·American Journal of Ophthalmology·Xiaoyong YuanAndrew J W Huang

❮ Previous
Next ❯

Citations

Apr 16, 2011·The Journal of Antimicrobial Chemotherapy·Josep Guarro
Jun 3, 2011·FEMS Microbiology Letters·Jennifer Luangsa-ArdRobert A Samson
Dec 3, 2016·Eye & Contact Lens·Rosa MonnoGiuseppe Miragliotta

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.