PMID: 6159783Nov 1, 1980Paper

Efficacy, plasma concentrations and adverse effects of a new sustained release procainamide preparation

The American Journal of Cardiology
E G GiardinaF I Marcus

Abstract

To assess the efficacy, plasma drug concentrations and adverse effects of a new sustained release preparation of procainamide, 33 patients with heart disease were studied in an acute dose-ranging protocol and a chronic treatment protocol. Patients initially received a daily dose of 3 g of sustained release procainamide; this dose was increased by 1.5 g daily until ventricular premature depolarizations were suppressed by 75 percent or more, adverse drug effects occurred or a total daily dose of 7.5 g of sustained-release procainamide was reached. Twenty-five patients (76 percent) had at least a 75 percent reduction (range 75 to 100percent [mean +/- standard deviation 91 +/- 8.2]) in ventricular permature depolarization frequency at a dosage of 4.8 +/- 1.46 g/day (range 3.0 to 7.5). Despite the 8 hour dosing interval, the variation between maximal and minimal plasma procainamide and N-acetylprocainamide concentrations under steady state conditions was very small. Mean maximal procainamide and N-acetylprocainamide plasma concentrations were 10.4 +/- 6.02 and 12.0 +/- 7.40 micrograms/ml, respectively. The respective mean minimal concentrations were 6.8 +/- 4.50 and 8.7 +/- 5.99 micrograms/ml. In nine patients (27 percent) treatment...Continue Reading

Citations

Apr 1, 1989·Cardiovascular Drugs and Therapy·L J JordaensD L Clement
Jan 1, 1983·Pharmacology & Therapeutics·D M Roden, R L Woosley
Jan 1, 1983·Journal of the American College of Cardiology·B Surawicz
Apr 1, 1994·Journal of Cardiovascular Electrophysiology·W GrimmF E Marchlinski
Mar 29, 2008·Drugs·Anna Legreid DoppJames E Tisdale
Aug 13, 1984·The American Journal of Cardiology·J C Somberg
Jun 1, 1983·American Heart Journal·B E Berger, D J Hauser
Jan 15, 1988·The American Journal of Cardiology·R DiBianco
Nov 28, 2006·Pharmacotherapy·Brady S MoffettNaomi J Kertesz
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Mar 1, 1986·Pacing and Clinical Electrophysiology : PACE·P R Kowey, T D Friehling
Oct 1, 1984·International Journal of Dermatology·P F Nestico, J Morganroth
Jul 1, 1982·Angiology·M N Cohen
Jan 1, 1984·Annals of the New York Academy of Sciences·E G Giardina
Sep 24, 1999·The Annals of Pharmacotherapy·E D BizjakJ M Galloway
Apr 1, 1983·Drug Intelligence & Clinical Pharmacy·M B BottorffR L Batenhorst

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