Efficacy profile of liposome bupivacaine, a novel formulation of bupivacaine for postsurgical analgesia.

Journal of Pain Research
Sergio D BergeseKeith A Candiotti

Abstract

Liposome bupivacaine is a novel formulation of the local anesthetic bupivacaine, designed to provide prolonged postsurgical analgesia. This analysis examined pooled efficacy data as reflected in cumulative pain scores from 10 randomized, double-blind liposome bupivacaine clinical studies in which the study drug was administered via local wound infiltration. A total of 823 patients were exposed to liposome bupivacaine in 10 local wound infiltration studies at doses ranging from 66 mg to 532 mg in five surgical settings; 446 patients received bupivacaine HCl (dose: 75-200 mg) and 190 received placebo. Efficacy measures were assessed through 72 hours after surgery. Overall, 45% of patients were male and 19% were ≥65 years of age. In the analysis of cumulative pain intensity scores through 72 hours, liposome bupivacaine was associated with lower pain scores than the comparator in 16 of 19 treatment arms assessed, achieving statistically significant differences compared with bupivacaine HCl (P < 0.05) in five of 17 treatment arms. These results were supported by results of other efficacy measures, including time to first use of opioid rescue medication, proportion of patients avoiding opioid rescue medication, total postsurgical con...Continue Reading

References

Jun 1, 1990·Diseases of the Colon and Rectum·J F ChesterJ C Gazet
May 23, 1998·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·L BeauregardM Choinière
Dec 4, 2004·Plastic and Reconstructive Surgery·Raman C MahabirWilliam E East
Aug 4, 2005·The Journal of Thoracic and Cardiovascular Surgery·Grayson H WheatleyJ Michael DiMaio

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Citations

Jan 16, 2014·Anesthesia Progress·Mana Saraghi, Elliot V Hersh
May 13, 2014·Best Practice & Research. Clinical Anaesthesiology·Yi Cai Isaac TongRichard D Urman
Oct 6, 2015·Expert Opinion on Drug Safety·Eugene R Viscusi
Oct 17, 2015·Current Medical Research and Opinion·Elliot V Hersh, Paul A Moore
Mar 5, 2016·Journal of Neurosurgery. Spine·Anthony N GrieffJack Jallo
Oct 29, 2015·The Annals of Thoracic Surgery·Kamal G KhalilHazim J Safi
Sep 28, 2015·The Orthopedic Clinics of North America·John W BarringtonRoger H Emerson
Apr 14, 2015·Clinical Therapeutics·Julie Golembiewski, Joseph Dasta
Jul 8, 2016·AJR. American Journal of Roentgenology·Mehran Midia, Dyda Dao
Aug 3, 2016·Pain Management·Gloria S Cheng, Brian M Ilfeld
Apr 6, 2018·Current Pain and Headache Reports·Sukanya MitraNalini Vadivelu
Jun 25, 2014·Hospital Pharmacy·John NoviaskyKenneth Hildreth
Feb 2, 2017·The Cochrane Database of Systematic Reviews·Thomas W HamiltonHemant G Pandit
Aug 4, 2018·Current Opinion in Anaesthesiology·Angela Lucia BaloccoAdmir Hadzic
Jul 24, 2015·Regional Anesthesia and Pain Medicine·Brian M IlfeldGirish P Joshi
Dec 4, 2015·Innovations : Technology and Techniques in Cardiothoracic and Vascular Surgery·Husam H BalkhyJohn Urban
Jun 25, 2016·Clinical Orthopaedics and Related Research·John W BarringtonKeith R Berend
Jan 23, 2020·Veterinary Medicine and Science·Tamara Grubb, Heidi Lobprise
Oct 11, 2013·Anesthesia and Analgesia·Brian M IlfeldSarah J Madison
Sep 1, 2017·Anesthesia Progress·Stuart E Lieblich, Hassan Danesi
Aug 24, 2016·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Gloria S Cheng, Brian M Ilfeld
Apr 16, 2019·Global Spine Journal·Luke BrownSteven Ludwig

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