Efficacy, Safety, and Economics of Intravenous Levetiracetam for Status Epilepticus: A Systematic Review and Meta-Analysis

Frontiers in Pharmacology
Zhan-Miao YiSuo-Di Zhai

Abstract

To evaluate efficacy, safety, and economics profiles of intravenous levetiracetam (LEV) for status epilepticus (SE). We searched PubMed, Embase, the Cochrane Library, Clinicaltrials.gov, and OpenGrey.eu for eligible studies published from inception to June 12th 2019. Meta-analyses were conducted using random-effect model to calculate odds ratio (OR) of included randomized controlled trials (RCTs) with RevMan 5.3 software. A total of 478 studies were obtained. Five systematic reviews (SRs)/meta-analyses, 9 RCTs, 1 non-randomized trial, and 27 case series/reports and 1 economic study met the inclusion criteria. Five SRs indicated no statistically significant difference in rates of seizure cessation when LEV was compared with lorazepam (LOR), phenytoin (PHT), or valproate (VPA). Pooled results of included RCTs indicated no statistically significant difference in seizure cessation when LEV was compared with LOR [OR = 1.04, 95% confidence interval (CI) 0.37 to 2.92], PHT (OR = 0.90, 95% CI 0.64 to 1.27), and VPA (OR = 1.47, 95% CI 0.81 to 2.67); and no statistically significant difference in seizure freedom within 24 h compared with LOR [OR = 1.83, 95% CI 0.57 to 5.90] and PHT (OR = 1.08, 95% CI 0.63 to 1.87). Meanwhile, LEV did not...Continue Reading

References

Sep 8, 2001·The New England Journal of Medicine·B K AlldredgeD H Lowenstein
Jan 12, 2005·Seizure : the Journal of the British Epilepsy Association·L T PenberthyR J DeLorenzo
Oct 20, 2005·The Cochrane Database of Systematic Reviews·K PrasadR Sequeira
Jan 5, 2007·Epilepsia·Mercè FalipIratxe Maestro
Feb 17, 2007·BMC Medical Research Methodology·Beverley J SheaLex M Bouter
Feb 23, 2008·Epilepsy & Behavior : E&B·Stephan RüeggPeter Fuhr
Jun 24, 2008·Epilepsy Research·Costas MichaelidesElizabeth A Thiele
Jul 22, 2008·Epilepsia·Simon ShorvonUNKNOWN TaskForce on Status Epilepticus of the ILAE Commission for European Affairs
Oct 28, 2008·Gerontology·Stefan BeyenburgNadja Maraite
Mar 7, 2009·Journal of Child Neurology·James W WhelessFred Perkins
Mar 28, 2009·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Nicholas S AbendDennis J Dlugos
May 19, 2009·Journal of Neurology, Neurosurgery, and Psychiatry·G MöddelS Happe
May 22, 2009·Journal of Neurology·Sascha BerningChristoph Kellinghaus
Jun 13, 2009·Pediatric Neurology·Batool F KirmaniHasan Rajab
Dec 26, 2009·Seizure : the Journal of the British Epilepsy Association·Manjari TripathiSarat P Chandra
Jan 7, 2010·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·H MeierkordUNKNOWN European Federation of Neurological Societies
Feb 11, 2010·Journal of Neuro-oncology·Justin B UseryChristopher K Finch
Apr 24, 2010·Journal of Child Neurology·Yu-tze NgKevin E Chapman
Jul 9, 2010·Pediatric Neurology·Pamela D ReiterRobert J Valuck
Mar 1, 2009·Therapeutic Advances in Neurological Disorders·Eugen Trinka, Judith Dobesberger
Mar 15, 2011·Pediatric Neurology·Owais KhanBatool Kirmani
Oct 20, 2011·BMJ : British Medical Journal·Julian P T HigginsUNKNOWN Cochrane Statistical Methods Group
Dec 20, 2011·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·J OlesenUNKNOWN European Brain Council
Feb 11, 2012·Seizure : the Journal of the British Epilepsy Association·Johan Zelano, Eva Kumlien
Feb 22, 2012·Epilepsy & Behavior : E&B·Christoph Kellinghaus, Florian Stögbauer
Apr 25, 2012·Neurocritical Care·Gretchen M BrophyUNKNOWN Neurocritical Care Society Status Epilepticus Guideline Writing Committee
Jun 23, 2012·Seizure : the Journal of the British Epilepsy Association·A McTagueR Appleton
Mar 27, 2013·BMJ : British Medical Journal·Don HusereauUNKNOWN CHEERS Task Force
May 15, 2013·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Abhijeet RakshasbhuvankarLakshmi Nagarajan
Nov 23, 2013·Pediatric Neurology·Esad KokluSelmin Koklu
Feb 20, 2014·Frontiers in Neurology·Laxmikant S Deshpande, Robert J Delorenzo
Aug 31, 2014·Pediatric Neurology·Rana İşgüderAycan Ünalp
Sep 11, 2014·The Cochrane Database of Systematic Reviews·Manya PrasadKhaldoon Al-Roomi
Jan 28, 2015·Expert Opinion on Pharmacotherapy·Iván Sánchez Fernández, Tobias Loddenkemper
Apr 23, 2015·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Sudheer ChakravarthiParampreet Singh
Apr 25, 2015·Lancet Neurology·John P Betjemann, Daniel H Lowenstein
Jun 17, 2015·Seizure : the Journal of the British Epilepsy Association·N LangU Stephani
Jun 20, 2015·Epilepsy Research·Murat Mert AtmacaCandan Gurses
Jul 5, 2015·Epilepsy & Behavior : E&B·Anne-Mari KantanenReetta Kälviäinen

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Citations

Feb 2, 2021·International Journal of Pharmaceutics·Kwadwo Amanor MfoafoHossein Omidian
Jul 6, 2021·Aging and Disease·Batool F KirmaniRobert J Delorenzo
Jul 3, 2021·Der Anaesthesist·Gabrielė SaitovDominik Michalski

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Software Mentioned

RevMan
Assessment of Multiple Systematic Reviews

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