Efficacy, safety, and impact on hospitalizations of paliperidone palmitate in recent-onset schizophrenia

Neuropsychiatric Disease and Treatment
Fan ZhangSteve Ascher

Abstract

To evaluate the efficacy, safety, and impact on hospitalizations of long-acting injectable paliperidone palmitate (PP) treatment, in patients with recent-onset schizophrenia who had not responded satisfactorily to oral antipsychotics. In this 18-month, open-label, Phase-IIIb study from Asia-Pacific region, patients (18-50 years) with recent-onset (≤5 years) schizophrenia unsatisfactorily treated with previous oral antipsychotics were initiated on PP 150 mg eq on day 1, 100 mg eq on day 8, followed by flexible once monthly maintenance doses of 50-150 mg eq. The number and duration of hospitalizations were compared using a mirror analysis method between two periods: retrospective (12 months before PP initiation) and prospective (12 and 18 months after PP treatment) periods. A total of 303 out of 521 (58%) patients (mean age, 28.7 years; 65.5% men, 92.5% Asian) completed the study. Positive and Negative Syndrome Scale (PANSS) total score improved significantly from baseline to month 18 (mean [standard deviation, SD] change: -11.3 [21.38], P<0.0001, primary endpoint). Subgroup analysis revealed greater improvements among patients with worse disease severity at baseline: PANSS ≥70 versus <70 (mean [SD] change: -23.1 [24.62] vs -4.7 ...Continue Reading

Citations

May 22, 2016·Expert Review of Clinical Pharmacology·Miquel Bernardo, Miquel Bioque
Dec 23, 2016·The Journal of Nervous and Mental Disease·Cynthia A BossieDong-Jing Fu
Nov 23, 2017·International Journal of Psychiatry in Clinical Practice·Eduard ParelladaUNKNOWN SHADOW Study Group
Sep 25, 2018·Expert Opinion on Pharmacotherapy·Miquel Bioque, Miquel Bernardo
Aug 2, 2017·Journal of Medical Economics·Thomas R EinarsonPieter J T Dries
Jul 22, 2016·European Psychiatry : the Journal of the Association of European Psychiatrists·F PietriniA Ballerini
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Methods Mentioned

BETA
pharmacotherapies
contraception

Clinical Trials Mentioned

NCT01051531

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Antipsychotic drugs are a class of medication primarily used to manage psychosis (including delusions, hallucinations, paranoia or disordered thought), principally in schizophrenia and bipolar disorder. Discover the latest research on antipsychotic drugs here

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