Abstract
To evaluate the efficacy, safety, and impact on hospitalizations of long-acting injectable paliperidone palmitate (PP) treatment, in patients with recent-onset schizophrenia who had not responded satisfactorily to oral antipsychotics. In this 18-month, open-label, Phase-IIIb study from Asia-Pacific region, patients (18-50 years) with recent-onset (≤5 years) schizophrenia unsatisfactorily treated with previous oral antipsychotics were initiated on PP 150 mg eq on day 1, 100 mg eq on day 8, followed by flexible once monthly maintenance doses of 50-150 mg eq. The number and duration of hospitalizations were compared using a mirror analysis method between two periods: retrospective (12 months before PP initiation) and prospective (12 and 18 months after PP treatment) periods. A total of 303 out of 521 (58%) patients (mean age, 28.7 years; 65.5% men, 92.5% Asian) completed the study. Positive and Negative Syndrome Scale (PANSS) total score improved significantly from baseline to month 18 (mean [standard deviation, SD] change: -11.3 [21.38], P<0.0001, primary endpoint). Subgroup analysis revealed greater improvements among patients with worse disease severity at baseline: PANSS ≥70 versus <70 (mean [SD] change: -23.1 [24.62] vs -4.7 ...Continue Reading
Citations
May 22, 2016·Expert Review of Clinical Pharmacology·Miquel Bernardo, Miquel Bioque
Feb 1, 2017·Expert Opinion on Drug Safety·M C MauriA C Altamura
Dec 23, 2016·The Journal of Nervous and Mental Disease·Cynthia A BossieDong-Jing Fu
May 17, 2018·Journal of Psychopharmacology·Tianmei SiYu Feng
Nov 23, 2017·International Journal of Psychiatry in Clinical Practice·Eduard ParelladaUNKNOWN SHADOW Study Group
Nov 5, 2017·Advances in Therapy·Hongyan ZhangYu Feng
Sep 25, 2018·Expert Opinion on Pharmacotherapy·Miquel Bioque, Miquel Bernardo
Sep 16, 2016·CNS Spectrums·Edward KimLarry Alphs
Aug 9, 2019·Expert Opinion on Pharmacotherapy·Nan LiWilson Tan
Jun 4, 2016·CNS Drugs·Eduard Parellada, Miquel Bioque
Aug 2, 2017·Journal of Medical Economics·Thomas R EinarsonPieter J T Dries
Nov 7, 2019·Journal of Clinical Psychopharmacology·Halise Devrimci-OzguvenMesut Yildiz
Jul 22, 2016·European Psychiatry : the Journal of the Association of European Psychiatrists·F PietriniA Ballerini
Apr 25, 2020·Clinical Psychopharmacology and Neuroscience : the Official Scientific Journal of the Korean College of Neuropsychopharmacology·Dasom LeeMyung Hun Jung
Jul 5, 2017·Hormone Molecular Biology and Clinical Investigation·Salvatore Gentile
Mar 11, 2020·Pharmacopsychiatry·Massimo Carlo MauriDario Cattaneo
Oct 17, 2018·NPJ Schizophrenia·Richard NewtonBenedicto Crespo-Facorro
Aug 18, 2017·International Clinical Psychopharmacology·Robin EmsleyMarta García-Dorado
Nov 17, 2017·Expert Opinion on Pharmacotherapy·Tianmei SiYu Feng
Jan 15, 2021·Early Intervention in Psychiatry·Wonsuk ShinMinji Bang
Apr 17, 2021·The Lancet. Psychiatry·Taishiro KishimotoChristoph U Correll