Efficacy, safety, and tolerability of imepitoin in dogs with newly diagnosed epilepsy in a randomized controlled clinical study with long-term follow up

BMC Veterinary Research
Chris RundfeldtWolfgang Löscher

Abstract

Imepitoin is a novel antiepileptic drug for the treatment of canine idiopathic epilepsy. The present study was conducted to demonstrate superior antiepileptic activity of a high dose of 30 mg/kg BID over a low dose of 1 mg/kg BID of imepitoin during 12 weeks of treatment under double blind conditions in a field population of dogs with previously untreated epilepsy. In a consecutive 12 weeks open label follow up (phase 2), all animals received 30 mg/kg BID, to evaluate the persistence of the antiepileptic activity, and to evaluate the effect of a dose step up to 30 mg/kg in the former low-dose animals. A treatment with 30 mg/kg BID resulted in a significantly greater reduction in monthly seizure frequency relative to baseline data as compared to the 1 mg/kg dose. Both generalized and partial seizures but not cluster seizures were significantly less frequent in the high dose group. The antiepileptic activity was maintained during study phase 2 in the high dose group. An increase to 30 mg/kg BID in the low- dose animals resulted in a significant reduction in generalized and partial seizures, but not cluster seizures. At the end of study phase 2, 32.1 and 46.8 % of dogs of the former high and former low-dose groups respectively, re...Continue Reading

References

Jul 26, 2002·Journal of the American Society of Nephrology : JASN·Andrew G BostomEberhard Ritz
Mar 1, 2003·Epilepsy & Behavior : E&B·Jorge G. BurneoEdward Faught
Apr 15, 2003·The Journal of Heredity·A M OberbauerT R Famula
Jan 22, 2005·Journal of Evaluation in Clinical Practice·Veronica Morton, David J Torgerson
May 21, 2005·The Veterinary Journal·Susanne RieckAndrea Tipold
Dec 18, 2007·Neurology·Rajesh Sachdeo
Nov 17, 2009·Journal of Veterinary Internal Medicine·K R MuñanaE E Patterson
Jul 2, 2011·The Journal of Veterinary Medical Science·Malte SchwartzNatasha J Olby
Dec 3, 2011·Journal of Veterinary Pharmacology and Therapeutics·H M WrightN M Davies
Dec 12, 2012·Polish Journal of Veterinary Sciences·H ZiółkowskiA Jasiecka
Jan 9, 2013·Epilepsia·Sonja SteinmetzWolfgang Löscher
Jan 10, 2013·The Veterinary Record·L Kearsley-FleetD C Brodbelt
Mar 20, 2013·Epilepsia·Heidrun PotschkaWolfgang Baumgärtner
Sep 28, 2013·Topics in Companion Animal Medicine·Christopher L Mariani
Sep 28, 2013·Topics in Companion Animal Medicine·Edward Ned E Patterson
Mar 13, 2014·Journal of Veterinary Pharmacology and Therapeutics·C RundfeldtP Wlaź
Aug 1, 2014·Journal of Veterinary Pharmacology and Therapeutics·A TipoldF de Vries
Oct 24, 2014·BMC Veterinary Research·Marios CharalambousHolger A Volk

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Citations

Feb 24, 2016·Journal of Veterinary Internal Medicine·M PodellS R Platt
Apr 23, 2020·Frontiers in Veterinary Science·Johannes Roland ErathAndrea Tipold
Jun 15, 2017·BMC Veterinary Research·Kevin J McPeake, Daniel S Mills

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