Efficacy, stability and predictors of outcome of pallidotomy for Parkinson's disease. Six-month follow-up with additional 1-year observations

Brain : a Journal of Neurology
A KishoreD B Calne

Abstract

We tested the efficacy, stability and predictors of outcome of unilateral pallidotomy used to treat patients with Parkinson's disease inadequately controlled with pharmacotherapy (IP). The surgical procedure was as simple as possible; we used CT rather than MRI, and we omitted microelectrode recording. We studied 24 patients with IP; 22 of these patients had drug-induced dyskinesias. There was a significant and stable improvement in all the major parkinsonian motor signs in the OFF (medication) state on the contralateral side. In the ON (medication) state peak-dose dyskinesias were alleviated on the contralateral side. The only significant and stable change on the ipsilateral side was improvement in dyskinesias less marked than on the contralateral side. The improvement in Unified Parkinson's Disease Rating Scale motor scores in the OFF state increased with age. The improvement in total dyskinesia scores occurred irrespective of age, but increased with duration of disease, duration of dyskinesias and baseline severity of dyskinesias. Five patients had transient neurological complications while facial paresis was permanent in one subject. Our results are similar to those obtained by others who used the time consuming microelectr...Continue Reading

Citations

Sep 24, 1999·Movement Disorders : Official Journal of the Movement Disorder Society·P R BurkhardJ W Tetrud
Dec 10, 1999·Movement Disorders : Official Journal of the Movement Disorder Society·R M de BieJ D Speelman
Jan 14, 2000·Movement Disorders : Official Journal of the Movement Disorder Society·P Martínez-MartínE Tolosa
Apr 7, 2000·Movement Disorders : Official Journal of the Movement Disorder Society·M S BaronM R DeLong
Mar 4, 1998·Annals of Neurology·P KrackA L Benabid
Oct 18, 2002·Microscopy Research and Technique·Estelle B Gauda
Jul 12, 2002·Movement Disorders : Official Journal of the Movement Disorder Society·Rob M A De BieJohannes D Speelman
Sep 5, 2002·Movement Disorders : Official Journal of the Movement Disorder Society·Simon G ParkinTipu Z Aziz
Aug 1, 1998·Movement Disorders : Official Journal of the Movement Disorder Society·P KrackA L Benabid
Oct 2, 1998·Movement Disorders : Official Journal of the Movement Disorder Society·E J SkalabrinJ P Bennett
Oct 20, 1999·Journal of Neurology·A E LangA M Lozano
Aug 22, 2003·Current Neurology and Neuroscience Reports·Helen Bronte-Stewart
Nov 30, 2000·Current Treatment Options in Neurology·S A Factor
Apr 9, 2008·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Robert E Gross
Sep 29, 1999·Journal of the Neurological Sciences·W C KollerA Albanese
Sep 29, 1999·Journal of the Neurological Sciences·J JankovicR Grossman
Jun 28, 2001·Clinical Biomechanics·M E MorrisR Iansek
Oct 28, 1999·Clinical Neurology and Neurosurgery·J A FieldsW C Koller
Jan 23, 1999·Current Opinion in Neurobiology·A M LozanoJ O Dostrovsky
Sep 23, 2003·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·J L MolinuevoJ Valls-Solé
Jan 24, 1998·The New England Journal of Medicine·B Müller-Oerlinghausen
Oct 15, 1998·The New England Journal of Medicine·A E Lang, A M Lozano
Sep 29, 2001·The New England Journal of Medicine·UNKNOWN Deep-Brain Stimulation for Parkinson's Disease Study GroupA E Lang
Sep 16, 1999·Journal of Neurology, Neurosurgery, and Psychiatry·A SchragN P Quinn
Aug 17, 2000·Journal of Neurology, Neurosurgery, and Psychiatry·G M RettigH S Levin
Aug 17, 2000·Journal of Neurology, Neurosurgery, and Psychiatry·P K PalD B Calne
Aug 21, 2001·Journal of Neurology, Neurosurgery, and Psychiatry·R M de BieUNKNOWN Dutch Pallidotomy Study Group
Apr 25, 2000·Annual Review of Medicine·K A Follett
Jul 23, 2005·Stereotactic and Functional Neurosurgery·Alexandre GironellJoan Molet
Dec 21, 2002·Neurosurgery·Zhang HuaWang Xuelian
Dec 1, 1974·Journal of Neurosurgery·J E AdamsH L Fields
Aug 5, 1999·Journal of Neurosurgery·C R HoneyD B Calne
Jan 9, 2001·Journal of Neurosurgery·A Alkhani, A M Lozano
Nov 12, 2013·Journal of Neurosurgery·Vincent A JourdainThérèse Di Paolo
Jun 5, 1998·Movement Disorders : Official Journal of the Movement Disorder Society·J D Speelman, D A Bosch
Apr 21, 1999·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·C Colosimo, M De Michele
Sep 7, 2000·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·C R Honey, R A Nugent
Aug 19, 1999·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·C HoneyA M Lozano

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