PMID: 8595647Sep 1, 1995Paper

Efficacy, tolerability, and effect on health-related quality of life of finasteride versus placebo in men with symptomatic benign prostatic hyperplasia: a community based study. CUSP Investigators. Community based study of Proscar

Clinical Therapeutics
C A ByrnesJ Y Gillenwater

Abstract

This study sought to assess the efficacy, tolerability, and effect of finasteride on health-related quality of life (HRQL) in a diverse population of men with moderate-to-severe symptomatic benign prostatic hyperplasia (BPH). This double-blind study evaluated finasteride and placebo for 12 months in 2342 men with BPH (16.2% black, 14.5% Hispanic, 69.3% Caucasian/other) in a community-based setting. At 3-month intervals, urinary symptoms were measured by use of the American Urologic Association symptom index. HRQL was assessed by use of the BPH impact index (BII), which evaluated degree of bother, worry, physical discomfort, and restriction in activities as a result of urinary symptoms. Additional questions regarding activities of living were administered, and global assessments of change in urologic status were performed by both patients and investigators. Compared with placebo, patients treated with finasteride had a statistically significant decrease in symptom scores when first measured at month 3. Symptom scores continued to improve in finasteride-treated patients throughout the study; at month 12, the mean decrease in symptom scores in the finasteride-treated patients was -4.8 compared with -3.4 for placebo patients ( P = ...Continue Reading

References

Dec 1, 1992·Journal of Clinical Epidemiology·R S EpsteinD Patrick
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Citations

Jun 19, 2009·International Journal of Impotence Research·T A Skolarus, J T Wei
Aug 15, 2014·Current Urology Reports·Charles WelliverKevin T McVary
Mar 23, 2011·The Journal of Sexual Medicine·Michael S Irwig, Swapna Kolukula
Nov 24, 2012·Expert Opinion on Drug Safety·Serap GurWayne Jg Hellstrom
Jun 24, 2015·Nature Reviews. Urology·Mary K Samplaski, Ajay K Nangia
Aug 1, 2016·The Urologic Clinics of North America·Charles Welliver, Ahmed Essa
Apr 11, 2013·The American Journal of Pathology·Kouji IzumiChawnshang Chang
Aug 23, 2003·International Journal of Impotence Research·D J Carbone, S Hodges
Oct 12, 2010·The Cochrane Database of Systematic Reviews·James TacklindTimothy J Wilt
Jan 1, 1997·Neurourology and Urodynamics·R Nelson
Feb 9, 2020·Fertility and Sterility·Abdulmaged M Traish

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