Efficacy, tolerability, and safety of cannabinoids in gastroenterology: A systematic review

Der Schmerz
M S VolzWinfried Häuser

Abstract

The medical use of cannabis is discussed in gastroenterology for inflammatory bowel diseases (IBD), irritable bowel syndrome (IBS), and chronic pancreatitis. A systematic literature search until March 2015 was performed in the databases Cochrane Central Register of Controlled Trials (CENTRAL), PubMed, www.cannabis-med.org , and clinicaltrials.gov. Randomized controlled trials (RCT) investigating herbal cannabis and/or pharmaceutical cannabinoids in IBD, IBS, or chronic pancreatitis with a study duration of ≥ 4 weeks and a sample size of at least n = 10 per study arm were identified. Clinical outcomes comprised efficacy (pain, nausea, appetite/weight, diarrhea, health-related quality of life, and remission rates for IBD), tolerability (drop-out rate due to side effects), and safety (severe side effects). Methodology quality of RCTs was evaluated with the Cochrane Risk of Bias Tool. Only one RCT treating 21 patients with Crohn's disease and herbal cannabis was identified. The study revealed no significant differences of remission rate because of low statistical power. However, there was a clear tendency for less abdominal pain and improved appetite with medical cannabis. The methodological risk of the study was high. Furthermore,...Continue Reading

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Citations

Jan 27, 2016·Der Schmerz·L Radbruch, M Schäfer
Nov 9, 2018·The Cochrane Database of Systematic Reviews·Tahir S KafilNilesh Chande
Jun 20, 2019·Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz·Eva HochUNKNOWN CaPRis-Projektgruppe
Feb 6, 2020·BMC Complementary Medicine and Therapies·Nadia Montero-OleasDaniel Simancas-Racines
Feb 20, 2021·Cancer Treatment and Research Communications·Timotius Ivan Hariyanto, Andree Kurniawan
Oct 14, 2021·Journal of Clinical Medicine·Paweł Kuźnicki, Katarzyna Neubauer

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