PMID: 28511169May 17, 2017Paper

Efficiency comparison of tofacitinib and budesonid in treatment of nonspecific ulcerative colitis

Wiadomości lekarskie : organ Polskiego Towarzystwa Lekarskiego
Andriy M Bratasiuk, Antonina I Niroda

Abstract

A constant interest to explore NUC is caused by the global trend showing a rise in colitis mobidity rate. According to a series of epidemiological studies, the highest incidence of NUC occurs in young age groups, which leads to significant loss of working capacity and high level of incapacitation. One of the leading roles in the pathogenesis of this disease is reportedly played by immunogenetic theory. To date, the main practical technique of NUC diagnostics is colonoscopy. To assess the activity level, the Mayo score is used most frequently. The aim of NUC treatment is to achieve and maintain remission as well as improve the patients' life quality. One of the main achievements of contemporary gastroenterology is practical introduction of such high-performance preparations as mononuclear antibodies to TNF- α. To compare the impact of tofacitinib and budesonid on the mucous membrane of NUC patients. Over the past two years 498 colonoscopic surveys have been performed at the Therapeutics Department of Uzhhorod Central Rayon Hospital, of which 16 patients have been chosen. Depending upon the treatment obtained, all the patients were divided into two groups: Group I - patients that were taking tofacitinib in constant doses of 10 mg...Continue Reading

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