Efficiency of antibacterial suture material in cardiac surgery: a double-blind randomized prospective study

The Heart Surgery Forum
Isil IsikCem Alhan

Abstract

Postoperative surgical site infections (SSI) still greatly affect mortality and morbidity in cardiovascular surgery. SSI may be related to the suture material. In this prospective, randomized, controlled, and double-blinded study, the effect of antibacterial suture material on SSI in cardiac surgical patients was investigated. We randomly allocated 510 patients into 2 groups. Antibacterial suture materials were used for wound closure in 170 patients (triclosan-coated suture group), and routine suture materials were used in 340 patients (noncoated suture group). All patients were evaluated for SSI on days 10, 20, and 30 following cardiac surgery. Preoperative risk factors and laboratory findings were comparable for the 2 groups. Sternal infection occurred in 4 (2.4%) of the patients in the triclosan-coated suture group and in 3.5% of the noncoated suture group (P > .05). Leg wound infection occurred in 5 (3.5%) of the patients in the triclosan-coated suture group and in 3.8% of the noncoated suture group (P > .05). Only diabetes mellitus was an independent predictor of SSI. Both noncoated and triclosan-coated suture materials are safe. Larger studies may be needed to show the benefit and cost-effectiveness, if any, of triclosan-...Continue Reading

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Citations

Feb 26, 2013·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Linda Thimour-BergströmAnders Jeppsson
Jul 16, 2014·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Ashima SinghBruce Y Lee
Feb 11, 2016·Journal of Biomedical Materials Research. Part a·Christopher DennisGeetha Manivasagam
Jan 31, 2015·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Anucha ApisarnthanarakGilbert Madriaga
Feb 26, 2016·Surgical Infections·Patrick B O'Neal, Kamal M F Itani
Sep 4, 2016·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·X WuJ Li
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Apr 13, 2017·Acta chirurgica Belgica·Athanasios A KonstanteliasSofia Mourgela
Feb 15, 2014·The Cochrane Database of Systematic Reviews·Kurinchi Selvan GurusamyBrian R Davidson
Oct 4, 2015·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·S SteingrimssonA Jeppsson
Nov 21, 2013·Annals of Surgery·Lucas TimmermansJohannes Jeekel

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