Efficiency of degradation or desorption methods in antineoplastic drug decontamination: A critical review

Journal of Oncology Pharmacy Practice : Official Publication of the International Society of Oncology Pharmacy Practitioners
Nicolas SimonSandrine Fleury-Souverain

Abstract

Although considerable efforts have been made over the last 40 years, occupational exposure to antineoplastic drugs is still a daily concern, since eradicating such contamination from workplaces seems unattainable. Considerable data are currently available on the risks associated with their use at work. Hospital facilities are often cleaned with marketed antimicrobials whose chemical decontamination efficacy certainly differs but remains unknown. To keep compounding facilities sterile, alcohol-based solutions are frequently used but with very limited efficiency. It would be particularly useful if a decontamination method could be added to the means already available so that all conventional antineoplastic drug contamination could be removed. Several degradation methods or desorption methods have previously been experimented, with varying success. They have never been compared or discussed in terms either of efficiency or usability. This review aims to analyse and discuss the results of each degradation or decontamination procedure and to compare them. This should facilitate selection of the method to be implemented in daily practice.

References

Jun 9, 1979·Lancet·K FalckL R Holsti
Oct 1, 1993·Journal of Pharmaceutical Sciences·M R CairaB van Oudtshoorn
Jan 1, 1997·International Archives of Occupational and Environmental Health·S HanselG Duménil
Jan 30, 2002·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Thomas H ConnorSusan M Spivey
Sep 3, 2002·Occupational and Environmental Medicine·E ZieglerP J Baxter
Sep 21, 2006·Journal of Oncology Pharmacy Practice : Official Publication of the International Society of Oncology Pharmacy Practitioners·Sarah RobertsGraham J Sewell
Dec 6, 2007·Journal of Oncology Pharmacy Practice : Official Publication of the International Society of Oncology Pharmacy Practitioners·UNKNOWN International Society of Oncology Pharmacy Practicioners Standards Committee
Dec 11, 2007·International Archives of Occupational and Environmental Health·M HedmerB A G Jönsson
Mar 9, 2010·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Rudolf SchierlElke Fischer
Oct 1, 2010·Journal of Occupational and Environmental Medicine·Melissa A McDiarmidCarmen Escalante
Apr 12, 2011·Toxicology Letters·Cristina SottaniClaudio Minoia
Apr 25, 2012·International Archives of Occupational and Environmental Health·Laetitia Minh Mai LêEric Caudron
Apr 20, 2013·Journal of Oncology Practice·Andrew C SegerJeffrey M Rothschild
May 17, 2013·Journal of Oncology Pharmacy Practice : Official Publication of the International Society of Oncology Pharmacy Practitioners·Sandrine Fleury-SouverainPascal Bonnabry
Aug 10, 2013·Journal of Oncology Pharmacy Practice : Official Publication of the International Society of Oncology Pharmacy Practitioners·Chun-Yip HonGeorge Astrakianakis
Jan 8, 2014·Journal of Oncology Pharmacy Practice : Official Publication of the International Society of Oncology Pharmacy Practitioners·Annie GuillemetteJean-François Bussières
Feb 13, 2014·Journal of Oncology Pharmacy Practice : Official Publication of the International Society of Oncology Pharmacy Practitioners·Bérengère DekyndtPascal Odou
Feb 26, 2014·Journal of Oncology Pharmacy Practice : Official Publication of the International Society of Oncology Pharmacy Practitioners·Paul Jm SessinkNassima Kassoul
Apr 15, 2014·Journal of Oncology Pharmacy Practice : Official Publication of the International Society of Oncology Pharmacy Practitioners·Hiroshi GohmaShin-Ichi Sugiura
Aug 26, 2014·Journal of Occupational and Environmental Medicine·Thomas H ConnorMelissa A McDiarmid
Mar 10, 2015·Journal of Occupational and Environmental Hygiene·Antje BöhlandtRudolf Schierl
Apr 22, 2015·Journal of Occupational and Environmental Hygiene·James M BoianoMarie H Sweeney
Dec 18, 2015·Journal of Oncology Pharmacy Practice : Official Publication of the International Society of Oncology Pharmacy Practitioners·Joshua CoxWilliam C Zamboni
Jan 8, 2017·Environmental Monitoring and Assessment·Petit MarieVanelle Patrice
Apr 5, 2017·International Journal of Hygiene and Environmental Health·Antje BöhlandtRudolf Schierl
Jun 1, 2017·The Analyst·Nicolas GuichardSandrine Fleury-Souverain

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Citations

Dec 19, 2019·Annals of Work Exposures and Health·Nicolas SimonSandrine Fleury-Souverain
Feb 23, 2020·Journal of Oncology Pharmacy Practice : Official Publication of the International Society of Oncology Pharmacy Practitioners·H BenoistG Saint-Lorant
Aug 26, 2020·European Journal of Hospital Pharmacy. Science and Practice·Nicolas SimonSandrine Fleury Souverain
Apr 14, 2020·Journal of Oncology Pharmacy Practice : Official Publication of the International Society of Oncology Pharmacy Practitioners·Ophélie PetitPascal Odou
Feb 12, 2021·Journal of Oncology Pharmacy Practice : Official Publication of the International Society of Oncology Pharmacy Practitioners·Claire ChabutJean-François Bussières
Dec 29, 2020·Journal of Occupational and Environmental Hygiene·Marie PalaminiJean-François Bussières
Mar 20, 2021·Clinical Journal of Oncology Nursing·Seth EisenbergAngela Rodriguez
Mar 20, 2021·International Archives of Occupational and Environmental Health·Lucie BláhováLuděk Bláha
Apr 22, 2021·Journal of Oncology Pharmacy Practice : Official Publication of the International Society of Oncology Pharmacy Practitioners·Victoire BéchetGuillaume Saint-Lorant
Oct 29, 2021·Journal of Oncology Pharmacy Practice : Official Publication of the International Society of Oncology Pharmacy Practitioners·Ginjiro KatoKazuki Akira

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