PMID: 2123819Nov 1, 1990Paper

Efficiency of enteral nitrogen support in surgical patients: small peptides v non-degraded proteins

Gut
F ZieglerJ Giboudeau

Abstract

In a prospective study, 12 intensive care patients, after abdominal surgery, received three alternate six-day courses of two enteral diets with identical nitrogen (0.3 g N/kg per day) and energy (60 kcal/kg per day) supply. The protein hydrolysate (PH) diet contained enzyme-hydrolysed casein and lactoserum (60% small peptides), while the non-degraded protein (NDP) diet contained a nitrogen source of similar amino acid composition, but in the form of non-degraded proteins. The patients were randomised to receive either PH-NDP-PH or NDP-PH-NDP. Parameters reflecting protein metabolism were assessed in the plasma, urine, and stomal effluent on days 1, 6, 12, and 18, three hours after stopping the nutrition (t0), and one hour after restarting it (t1). Comparisons of t1 and t0 values showed that 13 amino acids (including the eight essential amino acids) increased significantly with the protein hydrolysate diet, but only two increased with the non-degraded protein diet. Similarly, with protein hydrolysate, insulin-aemia at t1 was significantly higher than at t0 and correlated with plasma leucine, phenylalanine, alanine, and lysine concentrations. In addition, significant improvements in plasma albumin, transferrin, and retinol bindin...Continue Reading

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Citations

Feb 23, 2005·Nutrition·C LoïC Moinard
Mar 21, 1998·Journal of the American Dietetic Association·J E DietscherR W Smith
Nov 22, 2011·Nutrition Research Reviews·Rebecca L Thomson, Jonathan D Buckley
Nov 29, 2012·Journal of Neurotrauma·Christophe MoinardChristine Charrueau
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Mar 14, 2012·Medicina intensiva·L Bordejé LagunaUNKNOWN Spanish Society of Intensive Care Medicine and Coronary Units-Spanish Society of Parenteral and Enteral Nutrition (SEMICYUC-
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Mar 23, 2010·Molecular Nutrition & Food Research·Beatriz CabanillasCarmen Burbano
Apr 16, 2010·Journal of Hospital Medicine : an Official Publication of the Society of Hospital Medicine·Melissa A Munsell, Jonathan M Buscaglia
Jul 27, 2002·Critical Care Clinics·Jeffrey I Mechanick, Elise M Brett
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Jan 3, 2006·JPEN. Journal of Parenteral and Enteral Nutrition·Laurent-Eric TiengouMarie-Astrid Piquet
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Nov 23, 2006·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Jason M Hollander, Jeffrey I Mechanick
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Sep 30, 2005·Journal of Agricultural and Food Chemistry·José Miñones CondeJuan M Rodríguez Patino
Sep 28, 2006·Journal of Agricultural and Food Chemistry·Justo PedrocheFrancisco Millan

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