Efficiency of log wood combustion affects the toxicological and chemical properties of emission particles

Inhalation Toxicology
Maija TapanainenMaija-Riitta Hirvonen

Abstract

Particulate matter (PM) has been identified as a major environmental pollutant causing severe health problems. Large amounts of the harmful particulate matter (PM) are emitted from residential wood combustion, but the toxicological properties of wood combustion particles are poorly known. To investigate chemical and consequent toxicological characteristics of PM(1) emitted from different phases of batch combustion in four heating appliances. Mouse RAW264.7 macrophages and human BEAS-2B bronchial epithelial cells were exposed for 24 h to different doses (15-300 µg/mL) of wood combustion particles. After the exposure, cytotoxicity, genotoxicity, production of the inflammatory mediators (TNF-α and MIP-2) and effects on the cell cycle were assessed. Furthermore, the detected toxicological responses were compared with the chemical composition of PM(1) samples including PAHs, metals and ions. All the wood combustion samples exerted high cytotoxicity, but only moderate inflammatory activity. The particles emitted from the inefficient phase of batch combustion in the sauna stove (SS) induced the most extensive cytotoxic and genotoxic responses in mammalian cells. Polycyclic aromatic hydrocarbons (PAHs) and other organic compounds in PM...Continue Reading

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Citations

Apr 16, 2013·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Mikko HappoMaija-Riitta Hirvonen
Sep 26, 2015·The European Respiratory Journal·Torben SigsgaardBert Brunekreef
Oct 30, 2015·Particle and Fibre Toxicology·Ala MualaThomas Sandström

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