PMID: 8600351Feb 1, 1996Paper

Efficiency of MucAB and Escherichia coli UmuDC proteins in quinolone and UV mutagenesis in Salmonella typhimurium: effect of MucA and UmuD processing

Mutation Research
B ClerchM Llagostera

Abstract

The role of MucAB and Escherichia coli UmuDC proteins in mutagenesis by 4-quinolone (4-Q) compared to that in UV mutagenesis has been studied in hisG428 Salmonella typhimurium strains. A low-copy plasmid carrying mucAB genes, but not umuDC, promotes reversion of the hisG428 mutation by the 4-Q ciprofloxacin. In contrast, a umuDC plasmid mediates the reversion of hisG428 by UV, although less efficiently than a mucAB one. In addition, a unique copy of mucAB genes is enough to promote UV mutagenesis, whereas, several copies of them are required to detect ciprofloxacin mutagenesis. Therefore, the mutagenic repair of quinolone damage by MucAB proteins is not a very efficient process. The presence of an umuD'C plasmid but not a mucA'B one, slightly increases the reversion of the hisG428 mutation by ciprofloxacin and this finding is further discussed. In contrast, MucA'B are still more active than UmuD'C proteins in UV mutagenesis. These results suggest that the enhanced processing of MucA compared to UmuD would not explain all functional differences between MucAB and UmuDC proteins in the error-prone DNA repair.

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Citations

Jul 22, 1998·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·D ThieffryJ Collado-Vides
Sep 18, 1998·Electrophoresis·L TonellaD F Hochstrasser
Dec 15, 2004·Journal of Experimental Zoology. Part B, Molecular and Developmental Evolution·Phillip S PangAnna Marie Pyle
Jan 1, 1996·Protein Science : a Publication of the Protein Society·E V Koonin, K E Rudd
Aug 1, 2007·Applied Microbiology and Biotechnology·Marco OldigesChristiane Wiendahl
Apr 9, 2009·Applied Microbiology and Biotechnology·Kouta Hatayama, Tatsuo Yagishita
Jun 1, 2011·World Journal of Microbiology & Biotechnology·Drauzio E N Rangel
Oct 10, 2001·Progress in Lipid Research·R J HeathC O Rock
Apr 20, 2013·Chemical Reviews·Argyris Papantonis, Peter R Cook
Jun 29, 2000·Annual Review of Biochemistry·A KornbergD Ault-Riché
Jan 1, 1997·Annual Review of Genetics·D Romero, R Palacios
May 16, 2007·Physical Review Letters·Sidhartha Goyal, Ned S Wingreen
Apr 1, 2008·Nature Structural & Molecular Biology·Yuanbo CuiValentin V Rybenkov
Apr 13, 2012·Biotechnology and Bioengineering·Teresa ScholzCecília R C Calado

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