Efficiency of oxygen administration: sequential gas delivery versus "flow into a cone" methods

Critical Care Medicine
Marat SlessarevJoseph A Fisher

Abstract

Fio2 values of a new oxygen mask that exploits efficiencies afforded by sequential gas delivery (SGD) were compared to those of a nonrebreathing mask (NRM) and a Venturi oxygen mask. Prospective, single-blinded, randomized study. Laboratory study. Eight healthy male volunteers. Volunteers breathed through each of the masks at various minute ventilations (VE). Oxygen flows were 2, 4, and 8 L/min to the SGD mask but only 8 L/min to the other masks. Net FIO2 was calculated from end-tidal fractional concentrations of oxygen and CO2 with the alveolar gas equation. Only the SGD mask at an oxygen flow of 8 L/min consistently provided both FIO2>0.95 (at resting VE) and higher FIO2 than the other masks at all VE. The SGD mask delivered FIO2 comparable to other masks at only a fraction of the oxygen flow and was characterized by a consistent relation between FIO2 and oxygen flow for a given VE. We conclude that SGD can be exploited to provide FIO2>0.95 with oxygen flows as low as 8 L/min, as well as accurate and efficient dosing of oxygen even in the presence of hyperpnea.

References

Feb 1, 1978·Southern Medical Journal·J S ReddingC W Gross
Jul 1, 1975·Canadian Anaesthetists' Society Journal·H R WexlerA Aberman
May 1, 1989·Anaesthesia and Intensive Care·J MilrossP Donnelly
May 2, 1988·The Medical Journal of Australia·J Hunter, L G Olson
Nov 27, 1982·Lancet
Jun 30, 1984·Lancet·H A JonesJ M Hughes
Dec 1, 1984·British Journal of Anaesthesia·P G Lawler, J F Nunn
Oct 1, 1996·Journal of Applied Physiology·H F BeckerC E Sullivan
Nov 8, 2003·Critical Care Medicine·Sanjay ManochaJames A Russell
Aug 24, 2004·International Journal of Obstetric Anesthesia·E A MorrisS M Kinsella
Dec 16, 2004·Critical Care Medicine·Oleg V Evgenov
Jan 11, 2005·Critical Care Medicine·Christopher M Booth, Thomas E Stewart

❮ Previous
Next ❯

Citations

Dec 19, 2012·Medical Gas Research·Andrew R MartinJoëlle Texereau
Jul 10, 2014·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Tonny V VeenithJonathan P Coles
Oct 9, 2008·Experimental Eye Research·Subha T VenkataramanJohn G Flanagan
Apr 23, 2015·British Journal of Anaesthesia·A KurzUNKNOWN Factorial Trial Investigators
Jul 19, 2018·Anesthesiology·Annie J Sheeba, Satvinder Singh Bakshi
Dec 16, 2019·JACC. Cardiovascular Interventions·Joseph Fisher, Duminda N Wijeysundera
Jul 5, 2021·Respiratory Medicine·Yao-Chen WangYia-Ting Li

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.