May 28, 2019

Efficiency of platelet-rich plasma therapy in knee osteoarthritis does not depend on level of cartilage damage

Journal of Orthopaedic Surgery and Research
Rene BurchardJan Adriaan Graw

Abstract

Osteoarthritis of the knee is common and often leads to significant physical disability. While classic conservative therapeutic approaches aim for symptoms like pain and inflammation, procedures like the intraarticular application of hyaluronic acids (HA) or platelet-rich plasma (PRP) are thought to stimulate the endogenous HA production, stop catabolism of cartilage tissue, and promote tissue regeneration. To analyse whether the positive effects of PRP injections are associated with the level of cartilage damage, patient satisfaction with the treatment was correlated with the level of knee joint osteoarthritis quantified by MRI. PRP was performed with a low-leukocyte autologous conditioned plasma (ACP) system in 59 patients. A pre-treatment MRI was performed and a Whole-Organ MRI Score (WORMS) was used to score the level of knee osteoarthritis by 14 features: integrity of the cartilage, affection of the bone marrow, subcortical cysts, bone attrition, osteophytes, integrity of the menisci and ligaments, presence of synovitis, loose bodies, and periarticular cysts. A multivariate analysis with ordinary least squares regressions was used. Although pain symptoms and severity of clinical osteoarthritis symptoms decreased, regressio...Continue Reading

Mentioned in this Paper

Nuclear Magnetic Resonance Imaging Whole Body
Study
Intra-Articular Injections
Degenerative Polyarthritis
Magnetic Resonance Imaging
Bone Marrow
Injection Procedure
Hyaluronic Acid
Intra-articular
Cartilage Damage

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