Efficiency of the immunome protein interaction network increases during evolution.

Immunome Research
Csaba Ortutay, Mauno Vihinen

Abstract

Details of the mechanisms and selection pressures that shape the emergence and development of complex biological systems, such as the human immune system, are poorly understood. A recent definition of a reference set of proteins essential for the human immunome, combined with information about protein interaction networks for these proteins, facilitates evolutionary study of this biological machinery. Here, we present a detailed study of the development of the immunome protein interaction network during eight evolutionary steps from Bilateria ancestors to human. New nodes show preferential attachment to high degree proteins. The efficiency of the immunome protein interaction network increases during the evolutionary steps, whereas the vulnerability of the network decreases. Our results shed light on selective forces acting on the emergence of biological networks. It is likely that the high efficiency and low vulnerability are intrinsic properties of many biological networks, which arise from the effects of evolutionary processes yet to be uncovered.

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Citations

Jun 6, 2012·International Journal of Peptides·Mythily Srinivasan, A Keith Dunker
Mar 19, 2013·BMC Genomics·Piotr H PawlowskiPiotr Zielenkiewicz
Jan 13, 2009·BMC Immunology·Csaba Ortutay, Mauno Vihinen
Jan 21, 2011·Theoretical Biology & Medical Modelling·Virginia A FolcikClay B Marsh
Apr 2, 2011·BMC Medical Genomics·Trevor ClancyEivind Hovig
May 25, 2012·Human Mutation·Csaba Ortutay, Mauno Vihinen
Nov 18, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Crina SamarghiteanMauno Vihinen
Aug 18, 2018·Frontiers in Immunology·Gabriel Ndipagbornchi Teku, Mauno Vihinen

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