PMID: 9174286Apr 11, 1997Paper

Efficient assay for the determination of atenolol in human plasma and urine by high-performance liquid chromatography with fluorescence detection

Journal of Chromatography. B, Biomedical Sciences and Applications
F C ChiuK Raymond

Abstract

An efficient method for the determination of atenolol in human plasma and urine was developed and validated. alpha-Hydroxymetoprolol, a compound with a similar polarity to atenolol, was used as the internal standard in the present high-performance liquid chromatographic analysis with fluorescence detection. The assay was validated for the concentration range of 2 to 5000 ng/ml in plasma and 1 to 20 microg/ml in urine. For both plasma and urine, the lower limit of detection was 1 ng/ml. The intra-day and inter-day variabilities for plasma samples at 40 and 900 ng/ml, and urine samples at 9.5 microg/ml were <3% (n=5).

References

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Citations

Dec 24, 2004·Anesthesia and Analgesia·Marilyn GosgnachBertrand Diquet
Feb 14, 2007·Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry·Jianshe HuangTianyan You
Jan 3, 2016·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Alireza KhataeeSang Woo Joo
Dec 4, 2003·Journal of the American College of Cardiology·Luciano CominaciniVincenzo Lo Cascio
Nov 3, 2004·Analytical Biochemistry·Boontarika BoonyapiwatGlyn B Steventon

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