Abstract
Development of versatile and powerful nanoplatforms for efficient therapeutic delivery represents a major topic for current nanomedicine. Herein, we present the development of core-shell tecto dendrimers (CSTDs) for co-delivery of a therapeutic gene and drug for enhanced anticancer therapy applications. In this work, CSTDs were first prepared via supramolecular recognition of β-cyclodextrin (CD)-decorated generation 5 (G5) poly(amidoamine) (PAMAM) dendrimers as cores and adamantane (Ad)-functionalized G3 PAMAM dendrimers as shell components. The formed CSTDs with each G5 dendrimer surrounded with 4.2 G3 dendrimers were evaluated as a gene vector for delivery of plasmid DNA encoding enhanced green fluorescent protein as well as microRNA 21 inhibitor (miR 21i). We show that under an appropriate N/P ratio, the CSTDs enable effective transfection of both genetic materials to cancer cells. In particular, the transfection of miR 21i led to the inhibition of cancer cell migration, decreased miR 21 gene expression, and the effective regulation of the target genes and proteins (e.g., PTEN, PDCD4, p53, and Caspase-3). Furthermore, we revealed that the CSTDs were able to co-deliver miR 21i and an anticancer drug doxorubicin, leading to en...Continue Reading
References
Sep 1, 1993·Bioconjugate Chemistry·J Haensler, F C Szoka
Dec 22, 2007·Nature Reviews. Molecular Cell Biology·Richard J Youle, Andreas Strasser
Jan 12, 2008·Molecular Cancer Therapeutics·Paul E BlowerWolfgang Sadee
Jan 16, 2008·Biomaterials·Kenji KonoAtsushi Harada
May 21, 2008·Nano Letters·Yajun WangFrank Caruso
Jan 22, 2009·The Pharmacogenomics Journal·F PassettiF F Costa
Mar 2, 2011·Small·Liming ZhangZhijun Zhang
Mar 8, 2011·Cell·Douglas Hanahan, Robert A Weinberg
Aug 1, 2012·Nanomedicine·Donald A Tomalia
Oct 30, 2012·Molecular Oncology·Martin D Jansson, Anders H Lund
Feb 26, 2014·Biomaterials·Xiongwei DengYi Zeng
Mar 19, 2016·Drug Delivery·Lin WangDongSheng Zhou
Sep 27, 2016·Scientific Reports·T A NissinenJ J Hulmi
Nov 5, 2016·Nanomedicine·Lingdan KongXiangyang Shi
Dec 15, 2016·ACS Applied Materials & Interfaces·Rammohan DevulapallyRamasamy Paulmurugan
Jan 23, 2017·Molecular Therapy : the Journal of the American Society of Gene Therapy·Tae Jin LeeCarlo M Croce
Aug 22, 2017·Acta Biomaterialia·Xin LiXiangyang Shi
Oct 12, 2017·Nanoscale·M Martínez-CarmonaM Vallet-Regí
Mar 21, 2018·Theranostics·Lizhou LinLianfang Du
May 11, 2018·Oxidative Medicine and Cellular Longevity·Stefania GoriniElisabetta Ferraro
Jan 4, 2019·Journal of Cellular Physiology·Homa MollaeiZeinab Rostami
Nov 16, 2019·Nanoscale·Jianhong WangXiangyang Shi
Jan 14, 2019·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Dan LiXiangyang Shi
Sep 14, 2013·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Jingyi Zhu, Xiangyang Shi
May 7, 2016·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Wenxiu HouXiangyang Shi
Feb 28, 2017·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Benqing ZhouXiangyang Shi
Nov 21, 2017·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Feng ChenXiangyang Shi
Citations
Jul 18, 2020·Organic & Biomolecular Chemistry·Andrzej S SkwareckiMaria J Milewska
Sep 20, 2020·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Haonan LiKui Luo
Oct 19, 2020·European Journal of Medicinal Chemistry·Serge MignaniJean-Pierre Majoral
Jan 28, 2021·ACS Applied Materials & Interfaces·Zhijun OuyangXiangyang Shi
Jan 19, 2021·Bioconjugate Chemistry·Shewaye Lakew MekuriaXiangyang Shi
Nov 19, 2020·Small·Jin LiXiangyang Shi
Mar 7, 2021·International Journal of Molecular Sciences·Rebecca RaueBernhard Brüne
Apr 4, 2021·International Journal of Molecular Sciences·Piotr Tarach, Anna Janaszewska
Apr 4, 2021·Pharmaceutics·Veronica FollieroMassimiliano Galdiero
Apr 14, 2021·Biomacromolecules·Cong SongXiangyang Shi
Dec 24, 2020·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Xihui GaoChangyou Zhan
May 12, 2021·Advanced Healthcare Materials·Deidra M WardNicholas A Peppas
May 25, 2021·Materials Today. Bio·Zhijun OuyangXiangyang Shi
Jun 5, 2021·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Sunil Kumar DubeyPrashant Kesharwani
Jul 31, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Dayuan WangMingwu Shen
Apr 30, 2020·Biomacromolecules·Liang ChenXiangyang Shi
Jan 8, 2021·ACS Nano·Rebecca KaupAldrik H Velders
Aug 29, 2021·Pharmaceutics·Ana Raquel NevesDiana Costa
Nov 11, 2021·Biomacromolecules·Changsheng LiXiangyang Shi