Efficient construction of robust artificial neural networks for accurate determination of superficial sample optical properties

Biomedical Optics Express
Yu-Wen Chen, Sheng-Hao Tseng

Abstract

In general, diffuse reflectance spectroscopy (DRS) systems work with photon diffusion models to determine the absorption coefficient μa and reduced scattering coefficient μs' of turbid samples. However, in some DRS measurement scenarios, such as using short source-detector separations to investigate superficial tissues with comparable μa and μs', photon diffusion models might be invalid or might not have analytical solutions. In this study, a systematic workflow of constructing a rapid, accurate photon transport model that is valid at short source-detector separations (SDSs) and at a wide range of sample albedo is revealed. To create such a model, we first employed a GPU (Graphic Processing Unit) based Monte Carlo model to calculate the reflectance at various sample optical property combinations and established a database at high speed. The database was then utilized to train an artificial neural network (ANN) for determining the sample absorption and reduced scattering coefficients from the reflectance measured at several SDSs without applying spectral constraints. The robustness of the produced ANN model was rigorously validated. We evaluated the performance of a successfully trained ANN using tissue simulating phantoms. We a...Continue Reading

References

Jul 1, 1995·Computer Methods and Programs in Biomedicine·L WangL Zheng
Oct 1, 1994·Journal of the Optical Society of America. A, Optics, Image Science, and Vision·R C HaskellB J Tromberg
Oct 1, 1996·Physics in Medicine and Biology·A Kienle, M S Patterson
Jul 13, 2004·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Frédéric BevilacquaVasan Venugopalan
Mar 5, 2008·Journal of Biomedical Optics·Sheng-Hao TsengAnthony J Durkin
Jan 7, 2009·Journal of Biomedical Optics·Erik AlerstamStefan Andersson-Engels
Aug 19, 2009·Optics Express·Sheng-Hao TsengNikiforos Kollias
Jan 25, 2011·Biomedical Optics Express·Erik AlerstamLothar Lilge
Jun 29, 2012·Biomedical Optics Express·Quanzeng WangJoshua Pfefer

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Citations

Jul 5, 2016·Biomedical Optics Express·Pin-Yuan HuangSheng-Hao Tseng
Aug 5, 2017·Skin Research and Technology : Official Journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)·S-Y TzengS-H Tseng

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