Efficient control of Plasmodium yoelii infection in BALB/c and C57BL/6 mice with pre-existing Strongyloides ratti infection

Parasite Immunology
J KolbaumMinka Breloer

Abstract

About 225 million malaria cases have been reported worldwide in 2009, and one-third of the world's population is infected with parasitic helminths. As helminths and Plasmodium are co-endemic, concurrent infections frequently occur. Helminths have been shown to modulate the host's immune response; therefore, pre-existing helminth infections may interfere with the efficient immune response to Plasmodium. To study the interaction between helminths and Plasmodium, we established a murine model of co-infection using the gastrointestinal nematode Strongyloides ratti and Plasmodium yoelii. We show that a pre-existing Strongyloides infection slightly enhanced peak parasitemia and weight loss in P. yoelii-infected BALB/c mice, while disease progression was not altered in co-infected C57BL/6 mice. The Plasmodium-induced IFN-γ production and final clearance of Plasmodium infection were not affected by S. ratti co-infection in both C57BL/6 and BALB/c mice. Interestingly, the T helper cell (Th) 2 response induced by S. ratti was significantly suppressed upon P. yoelii co-infection. This suppressed Th2 response, however, was still sufficient to allow expulsion of S. ratti parasitic adults. Taken together, we provide evidence that simultaneou...Continue Reading

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Citations

Oct 3, 2014·BioMed Research International·Víctor H Salazar-CastañonMiriam Rodriguez-Sosa
Jul 26, 2016·Frontiers in Microbiology·Raquel A PinnaDalma M Banic
Feb 26, 2016·Parasitology·Minka Breloer, David Abraham
Aug 10, 2017·Frontiers in Cellular and Infection Microbiology·Norus AhmedSusanne Hartmann
Jun 16, 2019·Infectious Diseases of Poverty·Shi-Shi ShenZhi-Yue Lv

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