Efficient detection doxorubicin hydrochloride using CuInSe2 @ZnS quantum dots and Ag nanoparticles

Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
Guohua MiJun Fan

Abstract

Doxorubicin hydrochloride (DOX) is an effective anthracycline anticancer drug. However, the exceeded taken up could induce several side-effects such as cardiotoxicity, alopecia. Therefore, the level of DOX needs to be closely monitored to avoid the occurrence of its side-effects. Herein, we report a novel core CuInSe2 - shell ZnS quantum dots (CuInSe2@ZnS, QDs) and Ag nanoparticles (NPs) fluorescence sensor based on the surface plasmon resonance effect (SPR) of Ag NPs. The CuInSe2@ZnS QDs were prepared by water phase reflux method with the 3-mercaptopropionic acid (MPA) as stabilizer and ligand. The fluorescence intensity of CuInSe2@ZnS QDs/Ag NPs significantly reduced by DOX, which is mainly based on the electrostatic interaction between the DOX and fluorescence sensors. The inhibition of photoluminescence (ln F0/F) was linearly relationship to the concentration of DOX in the range of 2-100 μM with the detection limit as low as 0.05 μM. The as-prepared sensor has a high selectivity and sensitivity to DOX. Furthermore, the new sensor has been successfully applied to the determination of DOX in human serum samples with satisfactory results. Our work provides a clue for developing a novel CuInSe2@ZnS QDs/Ag NPs based fluorescence...Continue Reading

Citations

Feb 19, 2021·Journal of Fluorescence·Ghasem Rezanejade BardajeeHossein Mahmoodian
Feb 20, 2021·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Guohua MiJun Fan
Jun 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Raybel MuñozJose A Rodriguez

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