Efficient drug delivery of β-estradiol encapsulated in Zn-metal-organic framework nanostructures by microwave-assisted coprecipitation method

Drug Design, Development and Therapy
Mehdi RanjbarAli Asadipour

Abstract

Metal-organic frameworks (MOFs) are structures made up of inorganic nodes, which can be either single ions or clusters of ions and organic linkers. This study reports on a novel processing route for producing β-estradiol encapsulated in Zn-MOF nanocomposites by microwave-assisted coprecipitation as a facile and fast method. Zn-MOF nanocomposites were synthesized with the aid of Zn(OAc)2⋅2H2O and 2,6-pyridine dicarboxylic acid ammonium as an organic ligand. Furthermore, we studied encapsulated β-estradiol which is one of the most important classes of estrogenic compounds that are used in the treatment of prostate cancer and breast cancer. The effects of β-estradiol concentration and microwave irradiation on the morphology, particle size, distribution, and in vitro photoluminescence spectroscopy experiments of β-estradiol entrapped in Zn-MOF nanocomposites were characterized by X-ray diffraction, scanning electron microscopy, transmission electron microscopy, ultraviolet-visible spectroscopy, Fourier transform infrared spectroscopy, and Brunauer-Emmett-Teller spectroscopy. These nanostructures can be a good option for thawing hydrophilic and hydrophobic drugs over time. Zn-MOF nanocomposites with high porosity, total pore volume ...Continue Reading

Citations

Sep 29, 2019·Biomolecules·Shima TavakolAlan Prem Kumar
Oct 15, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Bingyan YangYu Zhang

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Methods Mentioned

BETA
X-ray
electron
dynamic light scattering

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