Efficient ensemble system based on the copper binding motif for highly sensitive and selective detection of cyanide ions in 100% aqueous solutions by fluorescent and colorimetric changes

Analytical Chemistry
Kwan Ho Jung, Keun-Hyeung Lee

Abstract

A peptide-based ensemble for the detection of cyanide ions in 100% aqueous solutions was designed on the basis of the copper binding motif. 7-Nitro-2,1,3-benzoxadiazole-labeled tripeptide (NBD-SSH, NBD-SerSerHis) formed the ensemble with Cu(2+), leading to a change in the color of the solution from yellow to orange and a complete decrease of fluorescence emission. The ensemble (NBD-SSH-Cu(2+)) sensitively and selectively detected a low concentration of cyanide ions in 100% aqueous solutions by a colorimetric change as well as a fluorescent change. The addition of cyanide ions instantly removed Cu(2+) from the ensemble (NBD-SSH-Cu(2+)) in 100% aqueous solutions, resulting in a color change of the solution from orange to yellow and a "turn-on" fluorescent response. The detection limits for cyanide ions were lower than the maximum allowable level of cyanide ions in drinking water set by the World Health Organization. The peptide-based ensemble system is expected to be a potential and practical way for the detection of submicromolar concentrations of cyanide ions in 100% aqueous solutions.

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Citations

Aug 17, 2016·Environmental Science and Pollution Research International·Andrea Bencini, Vito Lippolis
Jul 1, 2020·Dalton Transactions : an International Journal of Inorganic Chemistry·Rana DalapatiShyam Biswas
Sep 12, 2020·Luminescence : the Journal of Biological and Chemical Luminescence·Yan LiuYao Xian Li
Feb 15, 2021·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Jun WangLin Chen
Aug 20, 2021·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Zhouquan GuoFang Liao

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