PMID: 8873414Sep 1, 1996Paper

Efficient induction of persistent and prenatal parvovirus infection in rats

Virus Research
D J GaertnerR O Jacoby


Parvoviruses are prevalent and disruptive infectious agents of laboratory rats. Risks to rat-based research from infection are increased by the persistence of virus in immune rats and by prenatal transmission of infection. The mechanisms leading to viral persistence and prenatal infection are poorly understood and have been difficult to study for lack of reliable and humane induction methods. We report here protocols for inducing persistent and prenatal infection without causing clinical disease using the UMass strain of rat virus (RV), a common rat parvovirus. Infant rats inoculated by the oronasal route at 6 days of age had greater than 90% prevalence of persistent infection. RV-UMass also induced intrauterine infection in pregnant rats inoculated by the oronasal route. Inoculation of dams at gestation day 9 frequently caused severe disease in the fetuses whereas inoculation at gestation day 12 caused primarily asymptomatic fetal infection that persisted post partum RV-UMass infection facilitates study of parvoviralhost interactions that are relevant to laboratory rats and which also may improve understanding of persistent and prenatal human parvovirus infection.


Nov 3, 1979·Lancet
Oct 11, 1992·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·H FadenL J Anderson
Jul 1, 1992·British Journal of Obstetrics and Gynaecology·A L MoreyK A Fleming
Jan 1, 1991·Archives of Virology·D J GaertnerA L Smith
Jan 1, 1991·Archives of Virology·R O JacobyA L Smith
Jan 1, 1989·Archives of Virology·D J GaertnerF X Paturzo
Sep 1, 1989·Virus Research·M E BloomJ B Wolfinbarger
Dec 1, 1974·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·I W McLean, P K Nakane
Mar 1, 1994·Reproductive Toxicology·E K Jordan, J L Sever
Apr 1, 1993·Virus Research·D J GaertnerJ L Brandsma
Sep 1, 1993·The Pediatric Infectious Disease Journal·W C KochJ Harger
Dec 1, 1964·Proceedings of the Society for Experimental Biology and Medicine·L KILHAM, V H FERM

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