Efficient inhibition of the development of cardiac remodeling by a long-acting calcium antagonist amlodipine

Hypertension
T YamazakiY Yazaki

Abstract

The purpose of the present study was to examine the effects of a long-acting calcium antagonist, amlodipine, on the development of cardiac remodeling. Dihydropyridine calcium antagonists have been used widely for many years in the treatment of hypertension and angina pectoris. It has been reported, however, that a prototype of dihydropyridines, nifedipine, does not reduce mortality of patients with ischemic heart disease, possibly because of reflex stimulation of the sympathetic nervous system. A calcium antagonist, amlodipine, has been reported to have potential benefits by virtue of a gradual onset of action and a long duration of effects. Amlodipine (8 mg/kg per day, once a day) or nifedipine (24 mg/kg per day, three times a day) was administered to spontaneously hypertensive 12-week-old rats for 12 weeks. Left ventricular wall thickness was measured by echocardiography, and relative amounts of myosin heavy chain isoforms were assessed by pyrophosphate gels. Expressions of "fetal type" genes and type 1 collagen gene were examined by Northern blot analysis. Amlodipine and nifedipine both markedly reduced systolic blood pressure. However, the decrease in systolic blood pressure caused by nifedipine continued for no more than 8...Continue Reading

References

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Citations

May 19, 2010·Internal and Emergency Medicine·Alberto MilanFranco Veglio
Jun 23, 2011·Cardiovascular Toxicology·Bhulan Kumar SinghSyed Ehtaishamul Haque
Nov 3, 2001·Journal of the American College of Cardiology·N NishikawaM Hori
Apr 28, 2001·Annals of Anatomy = Anatomischer Anzeiger : Official Organ of the Anatomische Gesellschaft·C A Mandarim-de-Lacerda, L M Pereira
Dec 10, 2015·Journal of Ethnopharmacology·Bhulan Kumar SinghSyed Ehtaishamul Haque
Jul 24, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Atsushi OginoHisayoshi Fujiwara
Nov 24, 1999·Pediatric Transplantation·D M SilversteinM S Polinsky
Sep 26, 2000·Molecular Genetics and Metabolism·P J LijnenR H Fagard

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