Apr 8, 2020

Genomic determinants of pathogenicity in SARS-CoV-2 and other human coronaviruses

BioRxiv : the Preprint Server for Biology
N. AuslanderEugene V. Koonin


SARS-CoV-2 poses an immediate, urgent and major threat to public health across the globe. Here we report an in-depth molecular analysis to reconstruct the evolutionary origins of the enhanced pathogenicity of SARS-CoV-2 and other coronaviruses that are severe human pathogens. Using integrated comparative genomics and machine learning techniques, we identify key genomic features that differentiate SARS-CoV-2 and the viruses behind the two previous coronavirus outbreaks, SARS-CoV and MERS-CoV, from less pathogenic coronaviruses. The identified features could be crucial elements of coronavirus pathogenicity and possible targets for diagnostics, prognostication and interventions.

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Computer Software
Genome-Wide Association Study
Muscle Rigidity
Laboratory Procedures
Projections and Predictions
Total Tissue

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