Efficient metal-free photochemical borylation of aryl halides under batch and continuous-flow conditions

Chemical Science
Kai ChenPengfei Li

Abstract

A rapid, chemoselective and metal-free C-B bond-forming reaction of aryl iodides and bromides in aqueous solution at low temperatures was discovered. This reaction is amenable to batch and continuous-flow conditions and shows exceptional functional group tolerance and broad substrate scope regarding both the aryl halide and the borylating reagent. Initial mechanistic experiments indicated a photolytically generated aryl radical as the key intermediate.

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Citations

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