Efficient microwave access to polysubstituted amidines from imidoylbenzotriazoles

The Journal of Organic Chemistry
Alan R KatritzkySandeep K Singh

Abstract

Microwave reactions of primary and secondary amines with imidoylbenzotriazoles 6a-w gave diversely substituted amidines 7a-Aa in 76-94% yields. Convenient preparations of a variety of amides 5a-Ab (87-96%) and imidoylbenzotriazoles 6a-w (56-95%) have also been developed using microwave irradiation under mild conditions and short reaction times. These results demonstrate further the advantages of microwave synthesis and introduce a new application of imidoylbenzotriazoles in the preparation of polysubstituted amidines.

References

Apr 17, 2001·The Journal of Organic Chemistry·A R KatritzkyS Busont
May 26, 2001·The Journal of Organic Chemistry·A R KatritzkyY Fang
Jun 30, 2001·The Journal of Organic Chemistry·A R KatritzkyM V Voronkov
Dec 26, 2001·Chemical Reviews·K Tanaka, F Toda
Jul 4, 2003·The Journal of Organic Chemistry·Alan R KatritzkyHai-Ying He
Jan 31, 2004·The Journal of Organic Chemistry·Alan R KatritzkySandeep K Singh
Jul 17, 2004·The Journal of Organic Chemistry·Alan R KatritzkyYu Ji
Oct 1, 1948·Journal of the Chemical Society·P OXLEYW F SHORT
Feb 1, 1949·Journal of the Chemical Society·P OXLEY, W F SHORT

❮ Previous
Next ❯

Citations

Mar 13, 2014·European Journal of Medicinal Chemistry·Sándor KunLászló Somsák
Sep 9, 2011·The Journal of Organic Chemistry·Xiaohu DengNeelakandha S Mani
Jul 13, 2013·The Journal of Organic Chemistry·Joseph E BanningMichael Rubin
May 30, 2008·Proceedings of the National Academy of Sciences of the United States of America·Alan R KatritzkyKenneth J Linthicum
Apr 2, 2014·Chemical Communications : Chem Comm·Muhammad SharifXiao-Feng Wu
Dec 8, 2015·The Journal of Organic Chemistry·Zi-Chao ShenYu Tang
Oct 14, 2010·Journal of Medical Entomology·Alan R KatritzkyKenneth J Linthicum
Feb 12, 2017·Organic & Biomolecular Chemistry·Nabajyoti HazarikaGakul Baishya
Oct 30, 2013·Organic & Biomolecular Chemistry·Monica PiloLidia De Luca
Oct 3, 2014·Molecular Diversity·Afshin Sarvary, Ali Maleki
Mar 6, 2008·The Journal of Organic Chemistry·Masaharu HashimotoYasutaka Ishii
Mar 12, 2008·The Journal of Organic Chemistry·Jie Gao, Guan-Wu Wang
Nov 18, 2006·The Journal of Organic Chemistry·Alan R KatritzkyAnamika Singh
Aug 24, 2010·Organic Letters·Qiang Zhu, Yixin Lu
Nov 23, 2010·The Journal of Organic Chemistry·Wei Ren, Motoki Yamane

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.