Efficient Multicomponent Synthesis of Diverse Antibacterial Embelin-Privileged Structure Conjugates.

Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry
Pedro Martín-AcostaAna Estévez-Braun

Abstract

A library of embelin derivatives has been synthesized through a multicomponent reaction from embelin (1), aldehydes and privileged structures such as 4-hydroxycoumarin, 4-hydroxy-2H-pyran-2-one and 2-naphthol, in the presence of InCl3 as catalyst. This multicomponent reaction implies Knoevenagel condensation, Michael addition, intramolecular cyclization and dehydration. Many of the synthesized compounds were active and selective against Gram-positive bacteria, including one important multiresistant Staphylococcus aureus clinical isolate. It was found how the conjugation of diverse privileged substructure with embelin led to adducts having enhanced antibacterial activities.

References

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Citations

Jul 27, 2021·Natural Product Research·N Jeelan BashaPrasanna Kumar

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Methods Mentioned

BETA
1
H
NMR

Software Mentioned

ACD40 Name - Pro
Jaguar

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