Efficient nanocarriers of siRNA therapeutics for cancer treatment

Translational Research : the Journal of Laboratory and Clinical Medicine
Md Abdus Subhan, V P Torchilin

Abstract

Nanocarriers as drug delivery systems are promising and becoming popular, especially for cancer treatment. In addition to improving the pharmacokinetics of poorly soluble hydrophobic drugs by solubilizing them in a hydrophobic core, nanocarriers allow cancer-specific combination drug deliveries by inherent passive targeting phenomena and adoption of active targeting strategies. Nanoparticle-drug formulations can enhance the safety, pharmacokinetic profiles, and bioavailability of locally or systemically administered drugs, leading to improved therapeutic efficacy. Gene silencing by RNA interference (RNAi) is rapidly developing as a personalized field of cancer treatment. Small interfering RNAs (siRNAs) can be used to switch off specific cancer genes, in effect, "silence the gene, silence the cancer." siRNA can be used to silence specific genes that produce harmful or abnormal proteins. The activity of siRNA can be used to harness cellular machinery to destroy a corresponding sequence of mRNA that encodes a disease-causing protein. At present, the main barrier to implementing siRNA therapies in clinical practice is the lack of an effective delivery system that protects the siRNA from nuclease degradation, delivers to it to cance...Continue Reading

Citations

Jan 10, 2020·Pharmaceutical Research·Céline LacroixThomas Trimaille
Oct 11, 2019·Precision Clinical Medicine·Qinqin PuMin Wu
Nov 11, 2020·Journal of Hematology & Oncology·Le ZhuQiong-Zhu Dong
Dec 9, 2020·Cancers·Amirhossein Bahreyni, Honglin Luo
Oct 24, 2020·ACS Combinatorial Science·Milad AshrafizadehPooyan Makvandi
Mar 14, 2021·Life Sciences·Md Abdus SubhanVladimir P Torchilin
Mar 17, 2021·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Dan WangBin Hong
Jun 17, 2020·Nanomedicine : Nanotechnology, Biology, and Medicine·Md Abdus Subhan, V P Torchilin
Apr 2, 2021·Expert Opinion on Drug Delivery· Neha DesaiAbdelwahab Omri
Jun 2, 2021·Journal of Hematology & Oncology·Zhe ChengYongheng Chen
May 28, 2021·European Journal of Pharmacology·Walhan AlshaerAbdalla Awidi
Jul 23, 2021·Journal of Controlled Release : Official Journal of the Controlled Release Society·Kristina ŽivojevićNikola Ž Knežević
Jul 5, 2021·International Journal of Pharmaceutics·Manon BergerGéraldine Piel
Oct 5, 2021·Expert Opinion on Drug Delivery·Yazid Zaiki, Tin Wui Wong

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