Efficient one-pot synthesis of 2,3-dihydropyrimidinthiones via multicomponent coupling of terminal alkynes, elemental sulfur, and carbodiimides

Journal of the American Chemical Society
Zitao WangZhenfeng Xi

Abstract

An organolithium-promoted multicomponent reaction (MCR) involving readily available terminal alkynes, elemental sulfur, and carbodiimides has been achieved for the first time. This MCR offers an atom-economic route to 2,3-dihydropyrimidinthiones which are difficult to access by other means via an interesting and useful C=N double bond cleavage and an sp(3) C-H bond functionalization of carbodiimides.

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Citations

Jun 27, 2017·Chemical Communications : Chem Comm·Jun-Rong ZhangRi-Yuan Tang
Oct 1, 2015·Chemical Communications : Chem Comm·Zhen ZhangZhenhua Zhang
Feb 24, 2015·Chemical Communications : Chem Comm·Shekaraiah DevariBhahwal Ali Shah
Jun 5, 2013·Dalton Transactions : an International Journal of Inorganic Chemistry·Kazumasa HayasakaHiroshi Nakazawa
Oct 7, 2010·Journal of Combinatorial Chemistry·Roland E DolleWei Zhang

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