Efficient parameter estimation in multiresponse models measuring radioactivity retention

Radiation and Environmental Biophysics
J M Rodríguez-Díaz, G Sánchez-León

Abstract

After incorporation of radioactive substances, workers are routinely checked by bioassays (isotopic activity excreted via urine, measurements of radionuclides retained in the whole body or in the lungs, etc.). From the results, the isotopic activity incorporated by the worker is inferred, as well as the values of other parameters related to the metabolism of the incorporated substance, using the 'response function'. This function depends on several factors and it is usually obtained by solving a system of linear differential equations, resulting from the compartmental model which describes the human body (or a part of it). The possibility of using different types of bioassays from the same worker improves estimation of some of the parameters that characterize the solution of the system of equations, specially the unknown incorporated activity to the system. The transfer coefficients are usually considered to be known, using the values that are published in the corresponding International Commission of Radiological Protection (ICRP) publication. In the present study some practical cases will be presented, and optimal design criteria are developed that allow taking the bio-samples at the most informative times. The methodology pr...Continue Reading

References

Oct 1, 1985·Physics in Medicine and Biology·P N BrownH B Griffith
Aug 27, 2003·Health Physics·Guillermo Sanchez, Jesus Lopez-Fidalgo
Feb 11, 2005·Journal of Biopharmaceutical Statistics·Robert Gagnon, Sergei Leonov
Sep 13, 2005·Health Physics·Jesus Lopez-Fidalgo, Guillermo Sanchez
Nov 25, 2005·Journal of Pharmacokinetics and Pharmacodynamics·Timothy H WaterhouseJohn A Eccleston
Nov 25, 2005·Journal of Pharmacokinetics and Pharmacodynamics·Lena E FribergStephen B Duffull
Dec 14, 2006·Health Physics·Guillermo Sanchez
Dec 22, 2006·Radiation Protection Dosimetry·G Sánchez, J M Rodríguez-Díaz
Sep 22, 2007·Journal of Biopharmaceutical Statistics·Valerii Fedorov, Sergei Leonov
Feb 20, 2014·British Journal of Clinical Pharmacology·Joakim NybergFrance Mentré
May 16, 2014·Biometrical Journal. Biometrische Zeitschrift·Juan M Rodríguez-Díaz, Guillermo Sánchez-León
Oct 24, 2015·Annals of the ICRP·F PaquetUNKNOWN ICRP
Jan 31, 2018·Annals of the ICRP·F PaquetUNKNOWN Authors on Behalf of ICRP

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