Efficient post-macrocyclization functionalizations of oxacalix[2]arene[2]pyrimidines

Organic Letters
Wim Van RossomWim Dehaen

Abstract

Diversely functionalized oxacalix[2]arene[2]pyrimidines have been synthesized starting from a bis(methylsulfanyl)-substituted oxacalix[4]arene by two efficient post-macrocyclization pathways. Functionalized aryl groups were introduced on the pyrimidine building block via Liebeskind-Srogl cross-coupling reactions, while a variety of O-, S-, N-, and C-nucleophiles were inserted on the calixarene skeleton by nucleophilic aromatic substitution reactions on the bis(methylsulfonyl)oxacalix[4]arene analogue.

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Citations

Mar 1, 2012·The Journal of Organic Chemistry·Wim Van RossomWim Dehaen
Sep 11, 2012·The Journal of Organic Chemistry·Mahendra P SonawaneWim Van Rossom
Oct 26, 2012·The Journal of Organic Chemistry·Deepali WaghrayWim Dehaen
Oct 25, 2008·Chemical Society Reviews·Wouter Maes, Wim Dehaen
Sep 26, 2008·Chemical Communications : Chem Comm·Mei-Xiang Wang
Dec 8, 2015·Chemistry : a European Journal·Joice ThomasWim Dehaen
Dec 11, 2008·Angewandte Chemie·Hana Prokopcová, C Oliver Kappe
Jul 23, 2013·Chemistry : a European Journal·Deepali WaghrayWim Dehaen
Apr 16, 2010·Chemistry : a European Journal·Thien H NgoWouter Maes
May 15, 2010·Chemistry : a European Journal·Qi-Qiang WangMei-Xiang Wang
Aug 25, 2015·The Journal of Organic Chemistry·Shin-Ichiro KatoYosuke Nakamura
Oct 19, 2011·Chemical Communications : Chem Comm·Joice ThomasWim Dehaen
May 9, 2019·Organic & Biomolecular Chemistry·Jiao-Xia MaYong Yang
Jul 5, 2012·Organic & Biomolecular Chemistry·Joice ThomasWim Dehaen
Mar 17, 2012·Dalton Transactions : an International Journal of Inorganic Chemistry·Ling-Wei KongKe Wen
Oct 28, 2009·The Journal of Organic Chemistry·En-Xuan ZhangMei-Xiang Wang
Jun 6, 2009·The Journal of Organic Chemistry·Bo YaoMei-Xiang Wang
Jan 2, 2010·The Journal of Organic Chemistry·Li-Xia WangMei-Xiang Wang
Mar 21, 2009·Organic Letters·Wim Van RossomWouter Maes
Dec 7, 2010·Organic Letters·Wim Van RossomWouter Maes

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