Efficient production of offspring from Japanese wild-derived strains of mice (Mus musculus molossinus) by improved assisted reproductive technologies

Biology of Reproduction
Ayumi HasegawaAtsuo Ogura

Abstract

Because the genetic diversity of the laboratory mouse (Mus musculus) is very limited, wild-derived strains from this genus could provide invaluable experimental models for studies of mouse genetics and epigenetics such as quantitative trait locus analysis. However, such strains generally show poor reproductive performance under conventional husbandry conditions, so their use for large-scale analyses has been limited. This study was undertaken to devise assisted reproductive technologies (ARTs) for the efficient production of offspring in two wild-derived strains, MSM/Ms and JF1/Ms (Mus musculus molossinus). First, as females of these strains are poor responders to equine chorionic gonadotropin (eCG) stimulation, we examined the efficiency of superovulation by injecting anti-inhibin serum followed by human chorionic gonadotropin (hCG). Approximately four to six times more oocytes were ovulated than with eCG-hCG treatment in both strains, reaching ∼25-30 oocytes per female. Consequently, the procedures for in vitro fertilization using these superovulated oocytes and cryopreservation of embryos and spermatozoa could be optimized for both of the wild-derived strains. However, MSM/Ms embryos but not JF1/Ms embryos failed to develop ...Continue Reading

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Citations

Mar 17, 2012·Biology of Reproduction·Monika A Ward
Mar 4, 2014·The Journal of Reproduction and Development·Ayumi HasegawaAtsuo Ogura
Dec 7, 2018·The Journal of Reproduction and Development·Shinya AyabeAtsushi Yoshiki
Aug 27, 2019·The Journal of Reproduction and Development·Keiji MochidaAtsuo Ogura
Aug 22, 2017·The Journal of Reproduction and Development·Ayumi HasegawaAtsuo Ogura
Nov 6, 2020·Reproduction in Domestic Animals = Zuchthygiene·Ruoxin JiaJianzhi Pan
Sep 18, 2021·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Saori Mizuno-IijimaAtsushi Yoshiki

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Methods Mentioned

BETA
gene modification

Software Mentioned

SPSS

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