Efficient synthesis of γ-keto sulfones by NHC-catalyzed intermolecular Stetter reaction

Organic Letters
Anup BhuniaAkkattu T Biju

Abstract

The N-heterocyclic carbene-catalyzed intermolecular Stetter reaction of aldehydes with α,β-unsaturated sulfones allows the atom-economic and selective formation of γ-keto sulfones in good yields. Key to the success of this unique transition-metal-free carbon-carbon bond-forming reaction is the right choice of the NHC precursor and base. The reaction tolerates a broad range of different aldehydes.

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Citations

Sep 25, 2017·Organic & Biomolecular Chemistry·Yulia A KonikDzmitry G Kananovich
Oct 12, 2013·Chemistry : a European Journal·Ulf Scheffler, Rainer Mahrwald
Jul 1, 2020·Chemical Communications : Chem Comm·Tamal Kanti Das, Akkattu T Biju
Apr 15, 2014·Chemistry, an Asian Journal·Qijian NiDieter Enders
Jan 29, 2013·Angewandte Chemie·Michael SchedlerFrank Glorius
Oct 22, 2020·Chemical Communications : Chem Comm·Chun ZhangJie Wu
Jan 29, 2021·Chemical Record : an Official Publication of the Chemical Society of Japan ... [et Al.]·Fabrizio VeticaMarta Feroci
Oct 23, 2019·The Journal of Organic Chemistry·Atanu BhaumikBhoopendra Tiwari
Oct 30, 2018·The Journal of Organic Chemistry·Atanu PatraAkkattu T Biju
May 22, 2013·Journal of the American Chemical Society·Junmin ZhangYonggui Robin Chi
May 21, 2015·Chemical Reviews·Darrin M FlaniganTomislav Rovis

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