Efficient synthesis of carbon-11 labelled acylsulfonamides using [11 C]CO carbonylation chemistry

Chemical Communications : Chem Comm
Berend van der WildtFrederick T Chin

Abstract

Herein, a novel method for carbon-11 labeling of acyl sulfonamides by a one-step insertive [11C]CO carbonylative cross-coupling reaction between aryl halides and sulfonamides is presented. Various model compounds as well as drug molecules LY573636 (tasisulam) and ABT-199 were obtained in excellent yields. This method provides a valuable and widely applicable contribution to the continuously expanding radiochemical toolbox for PET research.

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Citations

Mar 10, 2020·Nuclear Medicine and Biology·Jonas ErikssonOleksiy Itsenko
May 9, 2019·The Journal of Organic Chemistry·Luke S SchembriLuke R Odell

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Methods Mentioned

BETA
imaging technique

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