Efficient synthesis of galactosylceramide analogues for iNKT cell stimulation

Bioorganic & Medicinal Chemistry Letters
Wenlan ChenPeng George Wang

Abstract

Glycolipids are potential antigens for iNKT cells recognition and demonstrate important roles in both innate and adaptive immunity. However, the difficulties in the preparation of pure configuration defined glycolipids limit the exploration of their different profiles in activating iNKT cells. We report here a concise and stereospecific preparation of novel galactosylceramide analogues by oxime ligation. This strategy would provide an efficient way to generate varied glycolipid analogues with either synthetic or natural carbohydrates for biological evaluations.

Citations

Jul 14, 2012·Bioscience, Biotechnology, and Biochemistry·Takuya Tashiro
Dec 10, 2015·Organic & Biomolecular Chemistry·N Chen, J Xie
Nov 2, 2016·Organic & Biomolecular Chemistry·N Chen, J Xie
Mar 14, 2012·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yin-Cheng HuangChung-Shan Yu
Mar 12, 2011·Organic & Biomolecular Chemistry·Aline Banchet-CadedduArnaud Haudrechy
Jul 7, 2018·Chemical Reviews·Carmanah D HunterChristopher W Cairo

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