Efficient transmission of pandemic H1N1 influenza viruses with high-level oseltamivir resistance.

Journal of Virology
Christopher W SeibertNicole M Bouvier

Abstract

The limited availability of approved influenza virus antivirals highlights the importance of studying the fitness and transmissibility of drug-resistant viruses. S247N is a novel, naturally occurring N1 neuraminidase mutation that reduces oseltamivir sensitivity and greatly potentiates oseltamivir resistance in the context of the H275Y mutation. Here we show that highly oseltamivir-resistant viruses containing both the S247N and H275Y mutations transmit efficiently in the guinea pig transmission model.

References

Oct 9, 1999·Journal of Virology·E FodorA García-Sastre
Jun 21, 2006·Proceedings of the National Academy of Sciences of the United States of America·Anice C LowenPeter Palese
Aug 10, 2007·Journal of Virology·Bernadette Crescenzo-Chaigne, Sylvie van der Werf
Oct 24, 2007·PLoS Pathogens·Anice C LowenPeter Palese
Feb 6, 2009·Emerging Infectious Diseases·Siri H HaugeOlav Hungnes
Feb 14, 2009·Euro Surveillance : Bulletin Européen Sur Les Maladies Transmissibles = European Communicable Disease Bulletin·P KramarzB Ciancio
Apr 1, 2009·Emerging Infectious Diseases·Adam MeijerUNKNOWN European Influenza Surveillance Scheme
Dec 17, 2009·The New England Journal of Medicine·Quynh Mai LeUNKNOWN Vietnam H1N1 Investigation Team
Apr 23, 2010·Emerging Infectious Diseases·Michal MandelboimElla Mendelson
Sep 25, 2010·PLoS Pathogens·Maki KisoYoshihiro Kawaoka
Jan 7, 2011·The Journal of Infectious Diseases·Matthew J MemoliJeffery K Taubenberger
Aug 26, 2011·Journal of the Royal Society, Interface·Dennis L ChaoIra M Longini
Dec 30, 2011·The New England Journal of Medicine·Aeron C HurtAnne Kelso

❮ Previous
Next ❯

Citations

May 24, 2013·Journal of Virology·Christopher W SeibertPeter Palese
Feb 18, 2018·ChemMedChem·Ádám HadháziMark von Itzstein
Sep 14, 2017·Journal of the Science of Food and Agriculture·Emiko NagaiYuji Isegawa
Nov 11, 2020·Mass Spectrometry Reviews·Kevin M Downard
Mar 17, 2021·Analytical Methods : Advancing Methods and Applications·Kevin M Downard
Oct 5, 2013·The Journal of Organic Chemistry·Pal John Pal AdabalaB Mario Pinto

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antimicrobial Resistance

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.

Antivirals

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Antimicrobial Resistance (ASM)

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.

Antivirals (ASM)

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.