Effluent Tenascin-C Levels Reflect Peritoneal Deterioration in Peritoneal Dialysis: MAJOR IN PD Study

BioMed Research International
Ichiro HiraharaDaisuke Nagata

Abstract

Peritoneal deterioration causing structural changes and functional decline is a major complication of peritoneal dialysis (PD). The aim of this study was to explore effluent biomarkers reflecting peritoneal deterioration. In an animal study, rats were intraperitoneally administered with PD fluids adding 20 mM methylglyoxal (MGO) or 20 mM formaldehyde (FA) every day for 21 days. In the MGO-treated rats, tenascin-C (TN-C) levels in the peritoneal effluents were remarkably high and a cluster of TN-C-positive mesothelial cells with epithelial-to-mesenchymal transition- (EMT-) like change excessively proliferated at the peritoneal surface, but not in the FA-treated rats. Effluent matrix metalloproteinase-2 (MMP-2) levels increased in both the MGO- and FA-treated rats. In a clinical study at 18 centers between 2006 and 2013, effluent TN-C and MMP-2 levels were quantified in 182 PD patients with end-stage renal disease. Peritoneal function was estimated using the peritoneal equilibration test (PET). From the PET results, the D/P Cr ratio was correlated with effluent levels of TN-C (ρ = 0.57, p < 0.001) and MMP-2 (ρ = 0.73, p < 0.001). We suggest that TN-C in the effluents may be a diagnostic marker for peritoneal deterioration with EM...Continue Reading

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Citations

May 19, 2018·The Journal of Pathology·Sara NamvarSarah E Herrick
Jun 19, 2021·Open Medicine·Jianzhong LiGuoyuan Lu
Nov 9, 2021·American Journal of Physiology. Renal Physiology·Yizhen SangJun Wada

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Methods Mentioned

BETA
biopsy
enzyme-linked immunosorbent assay
electrophoresis
nuclear translocation

Software Mentioned

ImageJ
R
R Foundation for Statistical Computing

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