Abstract
Chemoresistance is a general health problem concerning infectious diseases and cancer treatments. In this context, the worldwide dissemination of < pandrug > and < multidrug> resistant pathogens has severely compromised the efficacy of our antimicrobial weapons and dramatically increased the occurence of therapeutic failure. To efficiently combat multi-resistant pathogens, it is necessary to clearly define the molecular basis of the general resistance mechanism associated with the expression of active efflux pumps, which strongly restrict the intracellular concentration of antimicrobial drugs. Several families of efflux systems capable of multiple drug extrusion have been described. The activity of some efflux systems requires ATP hydrolysis for drug transport while others require a sodium or proton antiport. In this review we focus on two important human pathogens, Plasmodium falciparum and Pseudomonas aeruginosa, which exhibit a high level of antimicrobial resistance associated with the expression of efflux mechanisms. The efflux mechanisms and the development of efflux pump inhibitors (EPIs) are discussed regarding these two pathogens.
Citations
May 20, 2009·Current Microbiology·Suzanne M Abdel MalekPhilip J Collier
Jun 15, 2010·Biochemistry·Prakash D NallathambyXiao-Hong Nancy Xu
Jul 30, 2011·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·Maria Rosalia PascaPiero Marone
Feb 24, 2011·Antimicrobial Agents and Chemotherapy·Aurélie PascualBruno Pradines
Jun 30, 2012·The European Respiratory Journal·Matthew N HurleyAlan R Smyth
Oct 22, 2011·International Journal of Molecular Sciences·Seong-Cheol ParkKyung-Soo Hahm
Jan 31, 2013·Future Medicinal Chemistry·Matthew Hurley, Alan Smyth
May 10, 2011·FEBS Letters·Jean-Michel BollaJean-Marie Pagès
Mar 18, 2009·Biochimica Et Biophysica Acta·Rajeev Misra, Vassiliy N Bavro
Jan 29, 2017·Bioorganic & Medicinal Chemistry Letters·Yinhu WangHenrietta Venter
Sep 15, 2010·The Analyst·Juan ZhaoXuemei Wang
May 21, 2010·Critical Reviews in Microbiology·Wei-Hua Zhao, Zhi-Qing Hu
Aug 17, 2019·The Journal of Infectious Diseases·Huan RenWeihui Wu
May 2, 2014·The Analyst·Feng DingXiao-Hong Nancy Xu
Jun 17, 2015·The Journal of Biological Chemistry·Damien RouxGerald B Pier
May 6, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Manuela CurcioGiuseppe Cirillo
Oct 20, 2018·Frontiers in Pharmacology·Daniel J MasonAndreas Bender
Nov 14, 2020·Genes·Mónica GalochaMiguel Cacho Teixeira
Feb 6, 2018·ACS Omega·Feng DingXiao-Hong Nancy Xu