Efflux pump as alternate mechanism for drug resistance in Mycobacterium tuberculosis

The Indian Journal of Tuberculosis
Akbar KanjiZahra Hasan

Abstract

Tuberculosis (TB) remains an important global public health issue with an approximate prevalence of 10 million people with TB worldwide in 2015. Since antibiotic treatment is one of the foremost tools for TB control, knowledge of Mycobacterium tuberculosis (MTB) drug resistance is an important component for disease control. Although gene mutations in specific loci of the MTB genomes are reported as the primary basis for drug resistance, additional mechanisms conferring resistance to MTB are thought to exist. Efflux is a ubiquitous mechanism responsible for innate and acquired drug resistance in prokaryotic and eukaryotic cells. MTB presents a large number of putative drug efflux pumps compared to its genome size. Bioinformatics-based evidence has shown an association between drug efflux and innate or acquired resistance in MTB. This review describes the recent understanding of drug efflux in MTB.

Citations

Sep 29, 2020·Frontiers in Microbiology·Francesca BoldrinRiccardo Manganelli
Dec 10, 2020·Computational and Structural Biotechnology Journal·Tanushree TunstallNicholas Furnham
Feb 13, 2021·Infection and Drug Resistance·Maria Carolina SiscoRafael Silva Duarte
Oct 13, 2021·FEMS Microbiology Reviews·Sille RemmMarkus A Seeger

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