Efflux pumps and antimicrobial resistance: Paradoxical components in systems genomics

Progress in Biophysics and Molecular Biology
Ritika KabraShailza Singh

Abstract

Efflux pumps play a major role in the increasing antimicrobial resistance rendering a large number of drugs of no use. Large numbers of pathogens are becoming multidrug resistant due to inadequate dosage and use of the existing antimicrobials. This leads to the need for identifying new efflux pump inhibitors. Design of novel targeted therapies using inherent complexity involved in the biological network modeling has gained increasing importance in recent times. The predictive approaches should be used to determine antimicrobial activities with high pathogen specificity and microbicidal potency. Antimicrobial peptides, which are part of our innate immune system, have the ability to respond to infections and have gained much attention in making resistant strain sensitive to existing drugs. In this review paper, we outline evidences linking host-directed therapy with the efflux pump activity to infectious disease.

Citations

Mar 3, 2020·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·Piyush BaindaraSanti M Mandal
Dec 6, 2019·Frontiers in Bioengineering and Biotechnology·Nutan Chauhan, Shailza Singh
Oct 18, 2020·The Protein Journal·Ritika Kabra, Shailza Singh
Jan 26, 2021·The Science of the Total Environment·José C J M D S Menezes, Vinícius R Campos
Aug 26, 2021·Current Microbiology·Maria Anndressa Alves AgrelesIsabella Macário Ferro Cavalcanti
Dec 3, 2021·Expert Review of Anti-infective Therapy·Brian M FordePatrick N A Harris
Dec 28, 2021·Tissue Barriers·Pownraj BrindangnanamMohane Selvaraj Coumar

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Methods Mentioned

BETA
gene knockout
454-sequencing

Software Mentioned

ResFinder

Related Concepts

Related Feeds

Antimicrobial Resistance (ASM)

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.

Antimicrobial Resistance

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.

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