Efforts To Access the Potent Antitrypanosomal Marine Natural Product Janadolide: Synthesis of Des-tert -butyl Janadolide and Its Biological Evaluation

ACS Omega
Paresh R AthawaleD Srinivasa Reddy

Abstract

To identify novel antitrypanosomal agents based on Janadolide, a potent macrocyclic polyketide-peptide hybrid, a macrolactonization strategy was explored. We prepared des-tert-butyl Janadolide and evaluated its antitrypanosomal activity. Our findings suggest that the tert-butyl group is necessary for the desired bioactivity.

References

Sep 28, 2001·Organic Letters·I PatersonM Tudge
Aug 21, 2010·Organic Letters·David M Hodgson, Tanzeel Arif
Jun 16, 2012·Organic Letters·Qinghui WangMichio Kurosu
Sep 26, 2012·Chemical Reviews·A ParentyJ-M Campagne
Mar 19, 2013·Chemical Communications : Chem Comm·Satish Chandra PhilkhanaD Srinivasa Reddy
Dec 4, 2015·The Journal of Organic Chemistry·B SeetharamsinghD Srinivasa Reddy

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Citations

Apr 4, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Manuel Jesús Chan-BacabBenjamín Otto Ortega-Morales
Apr 7, 2020·Organic Letters·Jonathan H ChungRichard J Payne

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Methods Mentioned

BETA
column chromatography
NMR
Assay

Software Mentioned

Chem Bio Draw Ultra

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