Efforts to counteract locally the effects of systemic immunosupression: a review on the use of imiquimod, a topical immunostimulator in organ transplant recipients

International Journal of Immunopathology and Pharmacology
M TrakatelliE Stockfleth

Abstract

The potent systemic immunosuppression therapy necessary to sustain a life-saving solid organ transplant is associated with an increased incidence of various infections including human papillomavirus infection and skin cancers in organ transplant recipients. Imiquimod, a topical agent that functions through local induction of a specific anti-viral or anti-tumor immune response, appears to be a promising therapeutic option that could potentially counteract in situ the effects of systemic immunosupression in this vulnerable group. Up-to-date studies using this local immune-response modifier in transplanted patients have yielded reassuring and encouraging results regarding its safety and efficacy in this population. However, in order to establish the use of imiquimod as a standard treatment option for organ transplant recipients, additional research and clinical trials are required.

References

Mar 1, 1990·Transplantation·M M HarteveltJ P Vandenbroucke
Dec 23, 1999·Clinical Immunology : the Official Journal of the Clinical Immunology Society·R P BurnsA A Gaspari
Jan 5, 2000·The Journal of Investigative Dermatology·H SuzukiD N Sauder
Jan 8, 2000·Annals of Internal Medicine·U R HenggeR Arndt
Jun 30, 2000·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·H M RamsayP N Harden
Nov 9, 2000·The British Journal of Dermatology·E StockflethT Meyer
Feb 24, 2001·Journal of the American Academy of Dermatology·A Mackenzie-WoodM L Owens
Jul 21, 2001·Journal of the American Academy of Dermatology·A S BoydL E King
Aug 13, 2002·International Journal of STD & AIDS·S L Gayed
Sep 25, 2002·Journal of the American Academy of Dermatology·Brian Berman, Joely Kaufman
Sep 25, 2002·Journal of the American Academy of Dermatology·Jennifer C ZampognaAshraf M Hassenein
Nov 28, 2002·International Journal of Dermatology·Stephen TyringKen Washenik
Dec 5, 2002·Clinical and Experimental Dermatology·M A Stanley
Mar 8, 2003·Archives of Dermatology·Ingrid H WolfHelmut Kerl
Mar 8, 2003·Archives of Dermatology·Juan-Carlos MartinezUNKNOWN Transplant-Skin Cancer Collaborative
Apr 25, 2003·The New England Journal of Medicine·Sylvie EuvrardAlain Claudy
Jul 2, 2003·Dermatology : International Journal for Clinical and Investigative Dermatology·Reinhard DummerGünter Burg
Jul 4, 2003·International Journal of Dermatology·Josef SeebergerJohannes Pammer
Aug 7, 2003·Journal of the National Cancer Institute·Margarete SchönMichael P Schön
Oct 23, 2003·Dermatology : International Journal for Clinical and Investigative Dermatology·U Borucki, D Metze
Nov 18, 2003·The British Journal of Dermatology·T SchmookE Stockfleth
Nov 18, 2003·The British Journal of Dermatology·C UlrichE Stockfleth
Jan 16, 2004·Clinical and Experimental Dermatology·A M PowellR J Barlow
Mar 17, 2004·Transplantation·Bettina M PrinzWerner Kempf
Apr 8, 2004·The Australasian Journal of Dermatology·Elizabeth Benson
Apr 21, 2004·Archives of Dermatology·Ulrich R Hengge, Jörg Schaller
Apr 30, 2004·Clinical and Experimental Dermatology·D Vidal, A Alomar
Jun 25, 2004·The British Journal of Dermatology·B DidonaR Cavalieri
Jul 20, 2004·Apoptosis : an International Journal on Programmed Cell Death·M P Schön, M Schön
Sep 30, 2004·Nature Immunology·Akiko Iwasaki, Ruslan Medzhitov
Jan 20, 2005·The British Journal of Dermatology·C A HarwoodC M Proby
Apr 1, 2005·The New England Journal of Medicine·Giovanni StalloneGiuseppe Grandaliano
Apr 22, 2005·Dermatologic Therapy·Bradley T Kovach, Thomas Stasko
Jun 28, 2005·Critical Reviews in Oncology/hematology·Gianni GerliniNicola Pimpinelli
Jan 28, 2006·The Journal of Investigative Dermatology·Thomas H ThatcherAnthony A Gaspari
May 10, 2006·Clinical and Experimental Dermatology·L S Gardner, P J Ormond
Aug 25, 2006·International Journal of Cancer. Journal International Du Cancer·Sam M Mbulaiteye, Eric A Engels
Apr 13, 2007·Transplant Infectious Disease : an Official Journal of the Transplantation Society·N BabelP Reinke
Apr 26, 2007·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Jacques Dantal, Erich Pohanka
Aug 9, 2007·Dermatology : International Journal for Clinical and Investigative Dermatology·Lilia Ben M'barekCeleste Lebbe

❮ Previous
Next ❯

Citations

Oct 10, 2015·Future Oncology·Dimitrios Papakostas, Eggert Stockfleth
May 31, 2017·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·A Mittal, O R Colegio
Nov 1, 2017·The British Journal of Dermatology·M BlombergUNKNOWN NCI Keratinocyte Carcinoma Consortium
Sep 7, 2018·The British Journal of Dermatology·M V HepptC Berking
Jan 25, 2011·Expert Opinion on Pharmacotherapy·Sven R Quist, Harald P Gollnick
Sep 11, 2019·Clinical Oncology : a Journal of the Royal College of Radiologists·L CollinsT Stasko

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinoma, Basal Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.

Antiphospholipid Syndrome

Antiphospholipid syndrome or antiphospholipid antibody syndrome (APS or APLS), is an autoimmune, hypercoagulable state caused by the presence of antibodies directed against phospholipids.